⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL774685 | 0.92 | — | — | |
| SCHEMBL1145973 | 0.90 | CXCR3 (0.46) | — | |
| SCHEMBL1145910 | 0.90 | — | — | |
| SCHEMBL1144548 | 0.79 | — | — | |
| SCHEMBL73140 | 0.78 | — | — | |
| SCHEMBL8677978 | 0.77 | ALDH1A1 (0.44) | — | |
| SCHEMBL7690640 | 0.77 | ALDH1A1 (0.45) | — | |
| SCHEMBL3035551 | 0.72 | — | — | |
| SCHEMBL3615821 | 0.72 | — | — | |
| SCHEMBL8141452 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11174272-B2 | 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-11-16 | — | — | US | disclosed |
| US-20210206781-A1 | 1-ARYLCARBONYL-4-OXY-PIPERIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | TAKEDA PHARMACEUTICALS CO (JP) | 2021-07-08 | — | — | US | disclosed |
| US-10717748-B2 | 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-07-21 | — | — | US | disclosed |
| US-20200157117-A1 | 1-ARYLCARBONYL-4-OXY-PIPERIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | TAKEDA PHARMACEUTICALS CO (JP) | 2020-05-21 | — | — | US | disclosed |
| US-10550129-B2 | 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-02-04 | — | — | US | disclosed |
| EP-2982666-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2019-08-07 | — | — | EP | disclosed |
| US-20190233436-A1 | 1-ARYLCARBONYL-4-OXY-PIPERIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | TAKEDA PHARMACEUTICALS CO (JP) | 2019-08-01 | — | — | US | disclosed |
| US-10273245-B2 | 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-04-30 | — | — | US | disclosed |
| US-20190071455-A1 | 1-ARYLCARBONYL-4-OXY-PIPERIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | TAKEDA PHARMACEUTICALS CO (JP) | 2019-03-07 | — | — | US | disclosed |
| US-10174004-B2 | Production method of pyridazinone compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-01-08 | — | — | US | disclosed |
| US-20050171132-A1 | Diaminopyrimidine derivatives as selective growth hormone secrectgogue receptor (GHS-R) antagonists | XIN ZHILI (US) | 2005-08-04 | — | — | US | disclosed |
| WO-2005030734-A1 | DIAMINOPYRIMIDINE DERIVATIVES AS SELECTIVE GROWTH HORMONE SECRECTGOGUE RECEPTOR (GHS-R) ANTAGONISTS | ABBOTT LABORATORIES (US) | 2005-04-07 | — | — | WO | disclosed |
| US-20050070712-A1 | Pyrimidine derivatives as ghrelin receptor modulators | ABBOTT LABORATORIES | 2005-03-31 | — | — | US | disclosed |
| WO-2004076421-A1 | HETEROCYCLIC AMIDES, METHOD FOR THE PRODUCTION THEREOF, SUBSTANCES CONTAINING SAID HETEROCYCLIC AMIDES, AND USE THEREOF AS PESTICIDES | BAYER CROPSCIENCE GMBH (DE) | 2004-09-10 | — | — | WO | disclosed |
| EP-1434485-A1 | NICOTINIC ACID-HETEROCYCLYL-AMIDES AND ANALOGOUS PYRIMIDINE DERIVATIVES SERVING AS PESTICIDES | Bayer CropScience GmbH (DE) | 2004-07-07 | — | — | EP | disclosed |
| US-20040006047-A1 | Heterocyclic amides, a process for their preparation, compositions comprising them and their use | MERIAL LIMITED | 2004-01-08 | — | — | US | disclosed |
| WO-2003028459-A1 | NICOTINIC ACID-HETEROCYCLYL-AMIDES AND ANALOGOUS PYRIMIDINE DERIVATIVES SERVING AS PESTICIDES | BAYER CROPSCIENCE GMBH (DE) | 2003-04-10 | — | — | WO | disclosed |
| US-6294567-B1 | CONTROLLING PLANT DISEASES AND GERMACIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2001-09-25 | — | — | US | disclosed |
| CN-1298395-A | Pyrazolone derivatives | SUMITOMO CHEMICAL CO (JP) | 2001-06-06 | — | — | CN | disclosed |
| EP-1072598-A1 | PYRAZOLINONE DERIVATIVES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2001-01-31 | — | — | EP | disclosed |