Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.72 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.52 |
| ▸ | PNMT | P11086 | 5/20 | 0.50 |
| ▸ | CD44 | P16070 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7746004 | 0.98 | CD274 (0.71) | CD274S1PR1PNMTCD44MAOB | |
| SCHEMBL22807512 | 0.84 | CD274 (1.00) | CD274S1PR1PNMTCD44MAOB | |
| SCHEMBL18554655 | 0.81 | CD274 (0.53) | CD274PNMTCD44MAOBADRA2A | |
| SCHEMBL6634850 | 0.81 | CD274 (0.67) | CD274PNMTCD44MAOB | |
| SCHEMBL18757033 | 0.80 | CD274 (0.70) | CD274PNMTCD44MAOB | |
| SCHEMBL4663734 | 0.78 | PNMT (0.59) | PNMTCD44MAOBADRA2AADRA2B | |
| SCHEMBL30593253 | 0.78 | PNMT (0.59) | PNMTCD44MAOBADRA2AADRA2B | |
| SCHEMBL24842360 | 0.78 | PNMT (0.56) | CD274PNMTCD44MAOBADRA2A | |
| SCHEMBL22866959 | 0.78 | CD274 (0.86) | CD274PNMTCD44MAOB | |
| SCHEMBL6209523 | 0.78 | ASIC3 (0.53) | CD274PNMTCD44MAOBADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |