SCHEMBL7743850

SCHEMBL7743850

Cc1cccc2oc3ccccc3c(=S)c12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.42
MAOA P21397 5/20 0.42
HPGD P15428 5/20 0.42
KDM4E B2RXH2 5/20 0.42
SMN1; SMN2 Q16637 4/20 0.42
HSD17B10 Q99714 3/20 0.42
MAPT P10636 2/20 0.42
GLA P06280 1/20 0.42
CYP3A4 P08684 1/20 0.42
PGAM1 P18669 1/20 0.42
CASP1 P29466 1/20 0.42
CASP7 P55210 1/20 0.42
MAOB P27338 1/20 0.40
CYP2A6 P11509 2/20 0.39
CYP1A2 P05177 2/20 0.39
RAB9A P51151 2/20 0.38
LMNA P02545 1/20 0.38
GAA P10253 2/20 0.36
USP2 O75604 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4961160 0.84 ALDH1A1 (0.48) ALDH1A1MAOAHPGDKDM4ESMN1; SMN2
SCHEMBL29487286 0.79 ALDH1A1 (0.56) ALDH1A1MAOAHPGDKDM4ESMN1; SMN2
SCHEMBL195537 0.79 ALDH1A1 (0.56) ALDH1A1MAOAHPGDKDM4ESMN1; SMN2
SCHEMBL24662703 0.78 ALDH1A1 (0.43) ALDH1A1MAOAHPGDKDM4ESMN1; SMN2
SCHEMBL10669828 0.77 MAOA (0.55) ALDH1A1MAOAHPGDKDM4ESMN1; SMN2
SCHEMBL21055936 0.77 AHR (0.48) ALDH1A1MAOAHPGDKDM4ESMN1; SMN2
SCHEMBL1794501 0.77 MAOA (0.63) ALDH1A1MAOAHPGDKDM4ESMN1; SMN2
SCHEMBL11161935 0.76 CYP3A4 (0.36) ALDH1A1HPGDKDM4EMAPTCYP3A4
SCHEMBL17166803 0.76 CYP2A6 (0.43) ALDH1A1CYP2A6CYP1A2
SCHEMBL18106195 0.73 TDP1 (0.51) ALDH1A1MAOAHPGDKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107522686-B Thioether compound and preparation method thereof 北京化工大学 2020-11-20 CN disclosed
EP-0948535-A4 NOVEL LANTHIONINE ANTIBIOTIC COMPOSITIONS AND METHODS UAB RESEARCH FOUNDATION (US) 2001-05-23 EP disclosed
EP-0948535-A1 NOVEL LANTHIONINE ANTIBIOTIC COMPOSITIONS AND METHODS THE UAB RESEARCH FOUNDATION (US) 1999-10-13 EP disclosed
WO-1998017685-A9 NOVEL LANTHIONINE ANTIBIOTIC COMPOSITIONS AND METHODS 1998-08-13 WO disclosed
WO-1998017685-A1 NOVEL LANTHIONINE ANTIBIOTIC COMPOSITIONS AND METHODS THE UAB RESEARCH FOUNDATION (US) 1998-04-30 WO disclosed
EP-0354458-A2 Photoinitiators with a combined structure MERCK PATENT GmbH (DE) 1990-02-14 EP disclosed
EP-0033720-B1 ESTERS, THIOESTERS AND AMIDES OF THIOXANTHONE CARBONXYLIC ACID, THEIR USE AS SENSITIZERS OR PHOTO INITIATORS AND POLYMERS CIBA-GEIGY AG (CH) 1984-03-07 EP disclosed