Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | THRA | P10827 | 8/20 | 0.58 |
| ▸ | THRB | P10828 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | RARB | P10826 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RARA | P10276 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30831068 | 1.00 | HSD17B10 (0.62) | HSD17B10THRATHRBKMT2ARARB | |
| SCHEMBL9258997 | 0.98 | HSD17B10 (0.65) | HSD17B10THRATHRBKMT2ARARB | |
| SCHEMBL2763138 | 0.94 | HSD17B10 (0.65) | HSD17B10THRATHRBKMT2ARARB | |
| SCHEMBL17457887 | 0.90 | HSD17B10 (0.74) | HSD17B10THRATHRBKMT2ARARB | |
| SCHEMBL253937 | 0.86 | KMT2A (0.61) | HSD17B10THRATHRBKMT2AMEN1 | |
| SCHEMBL11424105 | 0.86 | HSD17B10 (0.74) | HSD17B10THRATHRBKMT2ARARB | |
| SCHEMBL4185050 | 0.85 | THRA (0.70) | HSD17B10THRATHRBKMT2ARARB | |
| SCHEMBL8383207 | 0.85 | THRA (0.70) | HSD17B10THRATHRBKMT2ARARB | |
| SCHEMBL8558008 | 0.85 | LMNA (0.69) | HSD17B10KMT2ARARBMEN1ALDH1A1 | |
| SCHEMBL965858 | 0.85 | THRA (0.70) | HSD17B10THRATHRBKMT2ARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417192-B1 | DRUGS WITH PYRIMIDONE COMPOUNDS INHIBITORS OF THE ENZYME LDL PLA.SUB.2 AND THEREFORE OF USE IN TREATING ATHEROSCLEROSIS. | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-09 | — | — | US | disclosed |