Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | CCKBR | P32239 | 11/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
| ▸ | CCKAR | P32238 | 4/20 | 0.36 |
| ▸ | POLQ | O75417 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744124 | 1.00 | KCNH2 (0.55) | KCNH2CCKBRXIAPPSEN1PSEN2 | |
| SCHEMBL7744593 | 0.88 | KCNH2 (0.72) | KCNH2CCKBRPSEN1PSEN2APH1B | |
| SCHEMBL7744135 | 0.88 | KCNH2 (0.72) | KCNH2CCKBRPSEN1PSEN2APH1B | |
| SCHEMBL7743998 | 0.84 | KCNH2 (0.61) | KCNH2CCKBR | |
| SCHEMBL7744698 | 0.84 | KCNH2 (0.47) | KCNH2XIAPPOLQP2RX7 | |
| SCHEMBL8620108 | 0.84 | KCNH2 (0.77) | KCNH2CCKBR | |
| SCHEMBL8760273 | 0.80 | KCNH2 (0.75) | KCNH2CCKBRPSEN1PSEN2APH1B | |
| SCHEMBL7743995 | 0.78 | KCNH2 (0.36) | KCNH2CCKBRXIAPPSEN1PSEN2 | |
| SCHEMBL7744120 | 0.78 | KCNH2 (0.36) | KCNH2CCKBRXIAPPSEN1PSEN2 | |
| SCHEMBL7965787 | 0.74 | KCNH2 (0.85) | KCNH2CCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001010216-A1 | ANTIARRHYTHMIC COMPOUNDS | MERCK & CO., INC. (US) | 2001-02-15 | — | — | WO | disclosed |