Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8A | O60658 | 10/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | YTHDC1 | Q96MU7 | 4/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | PI4KA | P42356 | 1/20 | 0.50 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.50 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204689 | 0.89 | PDE8A (0.60) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1146681 | 0.89 | YTHDC1 (0.67) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13596788 | 0.88 | HDAC6 (0.57) | PDE8AYTHDC1ADORA2AHDAC1HDAC6 | |
| SCHEMBL2060472 | 0.88 | PDE4A (0.67) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21076723 | 0.86 | PDE8A (0.57) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23764385 | 0.85 | PDE8A (0.59) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL822875 | 0.85 | PDE8A (0.56) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2060105 | 0.84 | PDE8A (0.55) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25511872 | 0.83 | MEN1 (0.59) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4470318 | 0.81 | PDE8A (0.58) | PDE8APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090324551-A1 | TLR AGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090324551-A1 | TLR AGONISTS | TLR3, TLR1, TLR5 | PDE8A 2214/4885PDE4A 1351/4885PDE4B 1827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.