Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 8/20 | 0.41 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL5875237 | 1.00 | ALDH1A1 (0.71) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL28147135 | 1.00 | ALDH1A1 (0.71) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL125278 | 1.00 | ALDH1A1 (0.71) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL28826306 | 0.98 | ALDH1A1 (0.68) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL7744389 | 0.98 | ALDH1A1 (0.75) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL28246171 | 0.91 | ALDH1A1 (0.65) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL5874250 | 0.89 | ALDH1A1 (0.62) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL5874239 | 0.89 | ALDH1A1 (0.62) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL23944 | 0.87 | ALDH1A1 (0.94) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL29629071 | 0.87 | ALDH1A1 (0.94) | ALDH1A1TSHRKDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1192 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118661610-A | Shallow-buried drip irrigation high-yield cultivation method for mung beans | 赤峰市农牧科学研究所 | 2024-09-20 | — | — | CN | claimed |
| CN-117483377-A | Centralized air supply and exhaust system for multiple ventilating cabinets in laboratory | 青岛普莱斯特实验室设备有限公司 | 2024-02-02 | — | — | CN | claimed |
| CN-116171780-B | Control method and device for multi-smoke-oven combined sowing catalyst, storage medium and server | 中国气象局人工影响天气中心 | 2023-09-12 | — | — | CN | claimed |
| CN-116171780-A | Control method and device for multi-smoke-oven combined sowing catalyst, storage medium and server | 中国气象局人工影响天气中心 | 2023-05-30 | — | — | CN | claimed |
| WO-2022186882-A1 | POLY(ARYL ETHER) BASED POLYMERS AND ASSOCIATED METHODS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2022-09-09 | — | — | WO | claimed |
| WO-2022186881-A1 | POLY(ARYL ETHER) BASED POLYMERS AND ASSOCIATED GAS SEPARATION MEMBRANES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2022-09-09 | — | — | WO | claimed |
| EP-0436642-B1 | PRE-ACTIVATED THERAPEUTIC AGENTS DERIVED FROM PHOTOACTIVE COMPOUNDS | BAYLOR RES FOUND (US) | 1995-04-26 | — | — | EP | claimed |
| EP-0436642-A1 | PRE-ACTIVATED THERAPEUTIC AGENTS DERIVED FROM PHOTOACTIVE COMPOUNDS. | BAYLOR RES FOUND (US) | 1991-07-17 | — | — | EP | claimed |
| WO-1990003187-A1 | PRE-ACTIVATED THERAPEUTIC AGENTS DERIVED FROM PHOTOACTIVE COMPOUNDS | BAYLOR RESEARCH FOUNDATION (US) | 1990-04-05 | — | — | WO | claimed |
| EP-3402819-B1 | IMMUNE-STIMULATING HUMANIZED MONOCLONAL ANTIBODIES AGAINST HUMAN INTERLEUKIN-2, AND FUSION PROTEINS THEREOF | UNIV ZUERICH (CH) | 2026-05-27 | — | — | EP | disclosed |
| US-12637468-B2 | Substituted [1,2,4]triazolo[4,3-b]pyridazines as GABAA receptor modulators | Shanghai Simr Biotechnology Co., Ltd. (CN) | 2026-05-26 | — | — | US | disclosed |
| WO-2026103686-A1 | BICYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF | 上海宇道生物技术有限公司 | 2026-05-21 | — | — | WO | disclosed |
| WO-2026104020-A1 | METHOD FOR RECOMBINANT PRODUCTION OF NOVEL GLYCOLIPIDS | UNIVERSITÄT HOHENHEIM (DE) | 2026-05-21 | — | — | WO | disclosed |
| EP-3827390-B1 | SYSTEMS AND METHODS FOR SUPPORTING MULTIPLE AUTOMATED WORKFLOWS | LIFEFOUNDRY INC (US) | 2026-05-20 | — | — | EP | disclosed |
| US-5180733-A | Antidepressants or nervous systen disorders | ABBOTT LABORATORIES (US) | 1993-01-19 | — | — | US | disclosed |
| US-5033352-A | Electronic musical instrument with frequency modulation | YAMAHA CORPORATION (JP) | 1991-07-23 | — | — | US | disclosed |
| US-4772687-A | AZO DYES, COLORFAST | BAYER AKTIENGESELLSCHAFT (DE) | 1988-09-20 | — | — | US | disclosed |
| EP-0141041-A2 | X-ray lithographic apparatus | feinfocus Verwaltungs GmbH & Co. KG (DE) | 1985-05-15 | — | — | EP | disclosed |
| US-4088764-A | CARDIOVASCULAR DISORDERS, BETA-ADRENERGIC BLOCKING AGENTS, ANTIARRHYTHMIC AGENTS | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) | 1978-05-09 | — | — | US | disclosed |
| US-4066768-A | ADRENERGIC BLOCKING AGENTS, ANTIARRHYTHMIC | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) | 1978-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12637468-B2 | Substituted [1,2,4]triazolo[4,3-b]pyridazines as GABAA receptor modulators | GABRA6, GABRA1, GABRB1 | MEN1 4169/4885ALDH1A1 632/4885TSHR 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.