Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.54 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | GALR3 | O60755 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744582 | 1.00 | PDE3B (0.54) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| SCHEMBL7746515 | 0.78 | PDE3B (0.56) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| SCHEMBL7743969 | 0.78 | PDE3B (0.56) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| Siguazodan SCHEMBL1024118 | 0.77 | KDM4E (0.67) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| Siguazodan SCHEMBL12648714 | 0.77 | KDM4E (0.67) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| Siguazodan SCHEMBL149133 | 0.77 | KDM4E (0.67) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| Siguazodan SCHEMBL7744697 | 0.77 | KDM4E (0.67) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| Siguazodan SCHEMBL7744694 | 0.77 | KDM4E (0.67) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| SCHEMBL7744587 | 0.76 | PDE3B (0.63) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| SCHEMBL10353457 | 0.75 | PDE3B (0.71) | PDE3BPDE3ATNNC1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001011933-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING A 7-(2-AMINOETHYL)-BENZOTHIAZOLONE AND A PDE4 INHIBITOR | ASTRAZENECA UK LIMITED (GB) | 2001-02-22 | — | — | WO | disclosed |