Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 5/20 | 1.00 |
| ▸ | HTR2C | P28335 | 8/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31367896 | 1.00 | QDPR (1.00) | QDPRHTR2CSIGMAR1APPESR1 | |
| SCHEMBL27866836 | 0.85 | QDPR (0.73) | QDPRHTR2CSIGMAR1 | |
| SCHEMBL17397697 | 0.85 | QDPR (0.73) | QDPRHTR2CSIGMAR1 | |
| SCHEMBL10827686 | 0.81 | QDPR (0.69) | QDPRAPP | |
| SCHEMBL10407313 | 0.81 | QDPR (1.00) | QDPRHTR2CSIGMAR1 | |
| SCHEMBL8380936 | 0.81 | QDPR (1.00) | QDPRHTR2CSIGMAR1ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL10353907 | 0.80 | QDPR (0.67) | QDPRHTR2CAPP | |
| Hydrochloric Acid SCHEMBL17455197 | 0.79 | QDPR (0.96) | QDPRHTR2CSIGMAR1ESR1ESR2 | |
| SCHEMBL21228136 | 0.77 | HTR2C (0.66) | QDPRHTR2CSIGMAR1ESR1ESR2 | |
| SCHEMBL29914651 | 0.77 | HTR2C (0.66) | QDPRHTR2CSIGMAR1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502050-A | DIHYDROXYPHENYL-SUBSTITITED PYRIDINES OR QUINONES, HYPERTENSIVE AGENTS | CORNELL RESEARCH FOUNDATION, INC. (US) | 1996-03-26 | — | — | US | claimed |
| EP-0730451-A4 | BLOCKING UTILIZATION OF TETRAHYDROBIOPTERIN TO BLOCK INDUCTION OF NITRIC OXIDE SYNTHESIS | CORNELL RES FOUNDATION INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-5874433-A | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis | CORNELL RESEARCH FOUNDATION, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| US-5874433-A | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis | CORNELL RESEARCH FOUNDATION, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0730451-A1 | BLOCKING UTILIZATION OF TETRAHYDROBIOPTERIN TO BLOCK INDUCTION OF NITRIC OXIDE SYNTHESIS | CORNELL RESEARCH FOUNDATION, INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5502050-A | DIHYDROXYPHENYL-SUBSTITITED PYRIDINES OR QUINONES, HYPERTENSIVE AGENTS | CORNELL RESEARCH FOUNDATION, INC. (US) | 1996-03-26 | — | — | US | disclosed |
| US-5502050-A | DIHYDROXYPHENYL-SUBSTITITED PYRIDINES OR QUINONES, HYPERTENSIVE AGENTS | CORNELL RESEARCH FOUNDATION, INC. (US) | 1996-03-26 | — | — | US | disclosed |
| WO-1995014468-A1 | BLOCKING UTILIZATION OF TETRAHYDROBIOPTERIN TO BLOCK INDUCTION OF NITRIC OXIDE SYNTHESIS | CORNELL RESEARCH FOUNDATION INC. (US) | 1995-06-01 | — | — | WO | disclosed |