Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 3/20 | 0.73 |
| ▸ | HTR2C | P28335 | 8/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | KHK | P50053 | 2/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14956908 | 0.85 | QDPR (0.60) | QDPRHTR2CSIGMAR1KHKTGFBR1 | |
| SCHEMBL31367896 | 0.85 | QDPR (1.00) | QDPRHTR2CSIGMAR1 | |
| SCHEMBL7744628 | 0.85 | QDPR (1.00) | QDPRHTR2CSIGMAR1 | |
| SCHEMBL27866836 | 0.81 | QDPR (0.73) | QDPRHTR2CSIGMAR1KHK | |
| SCHEMBL4670817 | 0.81 | SIGMAR1 (0.57) | QDPRHTR2CSIGMAR1KHKTGFBR1 | |
| SCHEMBL31752730 | 0.81 | HTR2C (0.62) | QDPRHTR2CSIGMAR1KHKTGFBR1 | |
| SCHEMBL6434221 | 0.81 | HTR2C (0.62) | QDPRHTR2CSIGMAR1KHKTGFBR1 | |
| SCHEMBL20847821 | 0.81 | HTR2C (0.57) | QDPRHTR2CSIGMAR1KHKTGFBR1 | |
| SCHEMBL10407313 | 0.80 | QDPR (1.00) | QDPRHTR2CSIGMAR1TGFBR1ACVR1 | |
| SCHEMBL16434840 | 0.77 | HTR2C (0.57) | QDPRHTR2CSIGMAR1KHKTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164395-A1 | INDANE AND INDOLINE DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | Novartis AG (CH) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016001875-A1 | INDANE AND INDOLINE DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | NOVARTIS AG (CH) | 2016-01-07 | — | — | WO | disclosed |