Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 2/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.42 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGFR | P43088 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8061507 | 0.83 | CXCL8 (0.50) | CXCL8CAMK2AKMT2ARAB9ACHRM1 | |
| SCHEMBL8064201 | 0.82 | MMP2 (0.47) | CXCL8NPC1TDP1PTGS1AKR1C3 | |
| SCHEMBL8058401 | 0.82 | CXCL8 (0.46) | CXCL8CAMK2AMEN1KMT2ANPC1 | |
| SCHEMBL8061527 | 0.81 | MEN1 (0.45) | CXCL8CAMK2AMEN1KMT2ACHRM1 | |
| SCHEMBL8046728 | 0.80 | CXCL8 (0.46) | CXCL8CAMK2ASMN1; SMN2CHRM1AKR1B1 | |
| SCHEMBL8059158 | 0.78 | CXCL8 (0.44) | CXCL8CAMK2ACHRM1AKR1B1TDP1 | |
| SCHEMBL8058590 | 0.77 | NAPRT (0.51) | CXCL8 | |
| SCHEMBL8046814 | 0.76 | CXCL8 (0.58) | CXCL8CAMK2AMEN1KMT2ACHRM1 | |
| SCHEMBL7604656 | 0.75 | NR1H4 (0.45) | CXCL8NR1H4CAMK2ACYP1A2MEN1 | |
| SCHEMBL8059150 | 0.75 | CXCL8 (0.41) | CXCL8CAMK2AMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514160-A | — | — | 2002-05-14 | — | — | JP | claimed |
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | claimed |
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | claimed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | claimed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |