Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 2/20 | 0.46 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CFD | P00746 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058590 | 0.86 | NAPRT (0.51) | CXCL8POLBALDH1A1 | |
| SCHEMBL8061507 | 0.85 | CXCL8 (0.50) | CXCL8CAMK2ACHRM1AKR1B1FABP4 | |
| SCHEMBL8058401 | 0.84 | CXCL8 (0.46) | CXCL8CAMK2ACHRM1AKR1B1HTT | |
| SCHEMBL8064201 | 0.82 | MMP2 (0.47) | CXCL8POLBL3MBTL1ALDH1A1 | |
| SCHEMBL8061525 | 0.81 | CXCL8 (0.45) | CXCL8CAMK2AABCB1FABP4FABP5 | |
| SCHEMBL8059158 | 0.80 | CXCL8 (0.44) | CXCL8CAMK2ACHRM1AKR1B1FABP4 | |
| SCHEMBL7744722 | 0.80 | CXCL8 (0.44) | CXCL8CAMK2ACHRM1AKR1B1SMN1; SMN2 | |
| SCHEMBL7605064 | 0.79 | KDM4E (0.46) | AKR1B1CFDPLGPLAUF11 | |
| SCHEMBL8061527 | 0.79 | MEN1 (0.45) | CXCL8CAMK2ACHRM1HTTFABP4 | |
| SCHEMBL8046814 | 0.78 | CXCL8 (0.58) | CXCL8CAMK2ACHRM1AKR1B1FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |