Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.42 |
| ▸ | RPA1 | P27694 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 2/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744751 | 0.87 | RAB9A (0.51) | NPC1RAB9AMAPTSMN1; SMN2PPP1CA | |
| SCHEMBL7744337 | 0.85 | RAB9A (0.49) | NPC1RAB9AMAPTSMN1; SMN2PPP1CA | |
| SCHEMBL574266 | 0.84 | NPC1 (0.60) | NPC1RAB9AMAPTRPA1L3MBTL1 | |
| SCHEMBL7746867 | 0.82 | NPC1 (0.58) | NPC1RAB9AMAPTL3MBTL1MYC | |
| SCHEMBL1898437 | 0.77 | NPC1 (0.78) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL14351864 | 0.73 | NPC1 (0.55) | NPC1RAB9AMAPTL3MBTL1HTR2A | |
| SCHEMBL3056530 | 0.73 | NPC1 (0.59) | NPC1RAB9AMAPTL3MBTL1HTR2A | |
| SCHEMBL17324806 | 0.71 | NPC1 (0.56) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL2865749 | 0.71 | SMN1; SMN2 (0.66) | SMN1; SMN2PPP1CARPA1L3MBTL1MEN1 | |
| SCHEMBL7746860 | 0.70 | NPC1 (0.56) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | claimed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | claimed |
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |