Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GRN | P28799 | 3/20 | 0.48 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6258641 | 0.90 | MAPT (0.64) | MAPTNPSR1POLBRAB9AKMT2A | |
| SCHEMBL2079137 | 0.88 | MAPT (0.62) | MAPTNPSR1RAB9AKMT2ANPC1 | |
| SCHEMBL7744958 | 0.88 | MAPT (0.61) | MAPTNPSR1POLBRAB9AKMT2A | |
| 4-Chloroaniline SCHEMBL7744339 | 0.79 | GRN (0.79) | MAPTNPSR1NPC1GRNSORT1 | |
| SCHEMBL5178107 | 0.79 | GRN (0.67) | MAPTNPSR1POLBRAB9AKMT2A | |
| SCHEMBL7744959 | 0.78 | NPSR1 (1.00) | MAPTNPSR1POLBRAB9AKMT2A | |
| SCHEMBL22000813 | 0.78 | HDAC3 (0.55) | MAPTNPSR1RAB9AKMT2ANPC1 | |
| SCHEMBL10150650 | 0.76 | MAPT (0.53) | MAPTNPSR1RAB9AKMT2ANPC1 | |
| SCHEMBL2336029 | 0.74 | MAPT (0.59) | MAPTNPSR1POLBRAB9AKMT2A | |
| SCHEMBL7240050 | 0.74 | P2RY14 (0.52) | MAPTNPSR1POLBRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |