Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | FLT1 | P17948 | 1/20 | 0.65 |
| ▸ | KDR | P35968 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 2/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900773 | 0.95 | NPSR1 (0.90) | NPSR1MAPTKMT2ANPC1RAB9A | |
| SCHEMBL146791 | 0.88 | NPSR1 (0.78) | NPSR1MAPTKMT2ANPC1RAB9A | |
| SCHEMBL144387 | 0.86 | NPSR1 (0.76) | NPSR1MAPTKMT2ANPC1RAB9A | |
| SCHEMBL1897882 | 0.81 | RAB9A (1.00) | NPSR1MAPTKMT2ANPC1RAB9A | |
| SCHEMBL147214 | 0.80 | MAPT (0.67) | NPSR1MAPTKMT2ANPC1RAB9A | |
| SCHEMBL147011 | 0.79 | NPSR1 (0.65) | NPSR1MAPTKMT2ANPC1RAB9A | |
| SCHEMBL6258641 | 0.79 | MAPT (0.64) | NPSR1MAPTKMT2ANPC1RAB9A | |
| SCHEMBL23846540 | 0.79 | NPSR1 (0.64) | NPSR1MAPTKMT2ANPC1RAB9A | |
| SCHEMBL7744394 | 0.79 | NPSR1 (0.64) | NPSR1MAPTKMT2ANPC1RAB9A | |
| 4-Chloroaniline SCHEMBL7744962 | 0.78 | MAPT (0.64) | NPSR1MAPTKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |