Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TASP1 | Q9H6P5 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1899142 | 0.83 | NPC1 (0.67) | TASP1NPSR1NPC1MAPTCRHBP | |
| SCHEMBL1898696 | 0.80 | TASP1 (0.81) | TASP1NPSR1NPC1MAPTCRHBP | |
| SCHEMBL1898402 | 0.79 | SMN1; SMN2 (0.52) | NPC1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1900846 | 0.75 | NPC1 (0.70) | TASP1NPSR1NPC1MAPTCRHBP | |
| SCHEMBL1899805 | 0.75 | NPC1 (0.72) | TASP1NPSR1NPC1MAPTCRHBP | |
| SCHEMBL1900139 | 0.75 | POLB (0.53) | NPSR1NPC1MAPTCNR1CNR2 | |
| SCHEMBL1898992 | 0.73 | NPC1 (0.68) | TASP1NPSR1NPC1MAPTCRHBP | |
| SCHEMBL10069051 | 0.72 | TASP1 (1.00) | TASP1NPSR1NPC1MAPTCRHBP | |
| SCHEMBL1899685 | 0.71 | NPSR1 (0.85) | TASP1NPSR1MAPTCRHBPCRHR2 | |
| SCHEMBL1898164 | 0.71 | NPSR1 (0.89) | TASP1NPSR1MAPTCRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |