Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 2/20 | 0.39 |
| ▸ | CPB1 | P15086 | 1/20 | 0.39 |
| ▸ | CPA3 | P15088 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PTPRA | P18433 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Catechol SCHEMBL21296992 | 0.80 | KDM4E (0.53) | SMN1; SMN2MAPTAKR1B1CYP2D6CYP2C19 | |
| SCHEMBL7745106 | 0.79 | GAA (0.37) | SMN1; SMN2MAPT | |
| Malic Acid SCHEMBL25410916 | 0.78 | AKR1B1 (0.69) | SMN1; SMN2MAPTAKR1B1CPA1CPB1 | |
| Salicylic Acid SCHEMBL10391921 | 0.78 | ALDH1A1 (0.62) | SMN1; SMN2MAPTAKR1B1CPA1 | |
| Salicylic Acid SCHEMBL27541069 | 0.77 | ALDH1A1 (0.51) | SMN1; SMN2MAPTCYP2D6 | |
| Diphenylamine SCHEMBL21145301 | 0.77 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTCPA1CPB1CPA3 | |
| Diphenylamine SCHEMBL21145303 | 0.77 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTCPA1CPB1CPA3 | |
| Salicylic Acid SCHEMBL15441407 | 0.77 | ALDH1A1 (0.60) | SMN1; SMN2MAPTAKR1B1CPA1 | |
| Naphthalene SCHEMBL2936422 | 0.76 | SMN1; SMN2 (0.65) | SMN1; SMN2CPA1CPB1CPA3CPB2 | |
| Malic Acid SCHEMBL27794963 | 0.75 | SMN1; SMN2 (0.88) | SMN1; SMN2KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062682-A4 | SELECTIVE SILICON OXIDE ETCHANT FORMULATION INCLUDING FLUORIDE SALT, CHELATING AGENT AND GLYCOL SOLVENT | ADVANCED TECH MATERIALS (US) | 2001-07-04 | — | — | EP | claimed |
| EP-1062682-A1 | SELECTIVE SILICON OXIDE ETCHANT FORMULATION INCLUDING FLUORIDE SALT, CHELATING AGENT AND GLYCOL SOLVENT | ADVANCED CHEMICAL SYSTEMS INTERNATIONAL CORPORATION (US) | 2000-12-27 | — | — | EP | claimed |
| WO-1999033094-A1 | SELECTIVE SILICON OXIDE ETCHANT FORMULATION INCLUDING FLUORIDE SALT, CHELATING AGENT AND GLYCOL SOLVENT | ADVANCED CHEMICAL SYSTEMS INTERNATIONAL INC. (US) | 1999-07-01 | — | — | WO | claimed |