Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480793 | 0.84 | CES1 (0.45) | TSHRPTK2BKMT2AMEN1ALDH1A1 | |
| SCHEMBL7745584 | 0.80 | TSHR (0.42) | TSHRPTK2BTP53KMT2AMEN1 | |
| SCHEMBL7741427 | 0.77 | MEN1 (0.40) | TSHRPTK2BKMT2AMEN1ALDH1A1 | |
| SCHEMBL7740991 | 0.77 | ALDH1A1 (0.49) | TSHRPTK2BKMT2AMEN1ALDH1A1 | |
| SCHEMBL7741461 | 0.73 | TSHR (0.48) | TSHRKMT2AMEN1ALDH1A1CYP3A4 | |
| SCHEMBL6481692 | 0.73 | KMT2A (0.45) | TSHRKMT2AMEN1CYP3A4SMN1; SMN2 | |
| SCHEMBL7741750 | 0.72 | CYP3A4 (0.44) | TSHRPTK2BTP53KMT2AMEN1 | |
| SCHEMBL7745632 | 0.71 | POLB (0.39) | TSHRTP53KMT2AMEN1ALDH1A1 | |
| SCHEMBL7746506 | 0.71 | MEN1 (0.39) | TSHRPTK2BTP53KMT2AMEN1 | |
| SCHEMBL7745897 | 0.70 | RAB9A (0.46) | TSHRPTK2BTP53KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774134-B2 | FOR THERAPY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-10 | — | — | US | disclosed |
| US-6774134-B2 | FOR THERAPY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-10 | — | — | US | disclosed |