Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7745656 | 0.89 | TDP1 (0.45) | TDP1CHRM1KMT2APOLBPKM | |
| SCHEMBL7746888 | 0.89 | TDP1 (0.45) | TDP1CHRM1KMT2APKMALDH1A1 | |
| SCHEMBL7746010 | 0.75 | NR4A2 (0.52) | POLBALDH1A1TOP2AHDAC1HDAC6 | |
| SCHEMBL7745992 | 0.74 | POLB (0.49) | PTGER4KMT2APOLBALDH1A1TOP2A | |
| SCHEMBL7115198 | 0.72 | TDP1 (0.55) | TDP1CHRM1KMT2APKMTSHR | |
| SCHEMBL7746533 | 0.72 | TDP1 (0.56) | TDP1CHRM1KMT2APKMALDH1A1 | |
| SCHEMBL3238752 | 0.71 | TDP1 (0.50) | TDP1CHRM1KMT2AALDH1A1LMNA | |
| SCHEMBL3238812 | 0.71 | CHRM1 (0.57) | TDP1CHRM1POLBGNRHRLMNA | |
| SCHEMBL7747969 | 0.70 | TOP2A (0.46) | KMT2APOLBPKMALDH1A1TOP2A | |
| SCHEMBL1481951 | 0.70 | LMNA (0.48) | TDP1CHRM1KMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774134-B2 | FOR THERAPY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-10 | — | — | US | disclosed |
| US-6774134-B2 | FOR THERAPY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-10 | — | — | US | disclosed |