Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD44 | P16070 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 2/20 | 0.43 |
| ▸ | ATP4A | P20648 | 1/20 | 0.39 |
| ▸ | ATP4B | P51164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247538 | 0.83 | CD44 (0.54) | CD44TAAR1ATP4AATP4BCYP3A4 | |
| SCHEMBL755515 | 0.81 | CD44 (0.52) | CD44TAAR1ATP4AATP4BCYP3A4 | |
| SCHEMBL29351040 | 0.81 | CD44 (0.52) | CD44TAAR1ATP4AATP4BCYP3A4 | |
| SCHEMBL751788 | 0.79 | CD44 (0.50) | CD44TAAR1ATP4AATP4BCYP3A4 | |
| SCHEMBL13783636 | 0.79 | CD44 (0.50) | CD44TAAR1ATP4AATP4BCYP3A4 | |
| SCHEMBL30961936 | 0.79 | CD44 (0.50) | CD44TAAR1ATP4AATP4BCYP3A4 | |
| SCHEMBL10423684 | 0.79 | CD44 (0.50) | CD44TAAR1ATP4AATP4BCYP3A4 | |
| Hydrochloric Acid SCHEMBL7642490 | 0.79 | CD44 (0.50) | CD44TAAR1ATP4AATP4BCYP3A4 | |
| SCHEMBL774586 | 0.79 | CD44 (0.50) | CD44TAAR1ATP4AATP4BCYP3A4 | |
| SCHEMBL15997 | 0.78 | TAAR1 (0.48) | CD44TAAR1PNMTDPP4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106883188-A | A kind of benzodiazepine compounds of 5 hydrogen 1,4 and its synthetic method | 上海交通大学 | 2017-06-23 | — | — | CN | claimed |
| EP-3875462-A1 | NUCLEOTIDE ANALOGS | The Regents of The University of California (US) | 2021-09-08 | — | — | EP | disclosed |
| CN-106902123-B | Application of 5-hydro-1, 4-benzodiazepine compound in treating liver cancer | 上海交通大学 | 2020-08-25 | — | — | CN | disclosed |
| CN-106883188-B | 5-hydrogen-1, 4-benzodiazepine compound and synthesis method thereof | 上海交通大学 | 2020-06-30 | — | — | CN | disclosed |
| EP-3466959-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | Janssen BioPharma, Inc. (US) | 2019-04-10 | — | — | EP | disclosed |
| EP-3013843-B1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | ALIOS BIOPHARMA INC (US) | 2018-05-30 | — | — | EP | disclosed |
| CN-106902123-A | Application of the benzodiazepine compounds of 5 hydrogen 1,4 in liver cancer is treated | 上海交通大学 | 2017-06-30 | — | — | CN | disclosed |
| CN-106883188-A | A kind of benzodiazepine compounds of 5 hydrogen 1,4 and its synthetic method | 上海交通大学 | 2017-06-23 | — | — | CN | disclosed |
| US-9023857-B2 | Substituted 6-(2-aminobenzylamino)purine derivatives, their use as medicaments and preparations containing these compounds | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2015-05-05 | — | — | US | disclosed |
| EP-2391626-B1 | SUBSTITUTED 6-(2-AMINOBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND PREPARATIONS CONTAINING THESE COMPOUNDS | Univerzita Palackého v Olomouci (CZ) | 2014-10-01 | — | — | EP | disclosed |
| CN-101155787-B | (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines | HOFFMANN LA ROCHE | 2010-11-24 | — | — | CN | disclosed |
| CN-101155787-A | (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines | HOFFMANN LA ROCHE (CH) | 2008-04-02 | — | — | CN | disclosed |
| US-7348332-B2 | (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines | HOFFMANN-LA ROCHSE INC. (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348332-B2 | (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines | HOFFMANN-LA ROCHSE INC. (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348332-B2 | (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines | HOFFMANN-LA ROCHSE INC. (US) | 2008-03-25 | — | — | US | disclosed |
| EP-1871748-A1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-INDAN-1-YL-AMINES | F. Hoffmann-Roche AG (CH) | 2008-01-02 | — | — | EP | disclosed |
| CN-1286815-C | 4-anilinoquinoline-3-carboxamides | ASTRAZENECA AB (SE) | 2006-11-29 | — | — | CN | disclosed |
| WO-2006108773-A1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-INDAN-1-YL-AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-10-19 | — | — | WO | disclosed |
| US-20060229323-A1 | (3,4-Dihydro-quinazolin-2-yl)-indan-1-yl-amines | F. HOFFMANN-LA ROCHE AG (CH) | 2006-10-12 | — | — | US | disclosed |
| CN-1507434-A | Novel 4-anilinoquinoline-3-carboxamides | — | 2004-06-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229323-A1 | (3,4-Dihydro-quinazolin-2-yl)-indan-1-yl-amines | HTR5A, HTR1A, HTR1E | CD44 3150/4885TAAR1 71/4885PNMT 454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.