Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | VNN1 | O95497 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7750817 | 0.94 | ALDH1A1 (0.52) | EGFRPOLBNR2F2ALDH1A1BDKRB1 | |
| SCHEMBL7752026 | 0.92 | SMN1; SMN2 (0.47) | EGFRPOLBNR2F2BDKRB1AURKA | |
| SCHEMBL7753170 | 0.89 | GSK3B (0.48) | EGFRPOLBNR2F2ALDH1A1BDKRB1 | |
| SCHEMBL7750846 | 0.88 | HPGD (0.47) | EGFRPOLBNR2F2ALDH1A1BDKRB1 | |
| SCHEMBL7753157 | 0.88 | BDKRB1 (0.53) | EGFRPOLBALDH1A1BDKRB1SMN1; SMN2 | |
| SCHEMBL7751822 | 0.87 | BDKRB1 (0.46) | EGFRPOLBALDH1A1BDKRB1HPGD | |
| SCHEMBL7746182 | 0.83 | BDKRB1 (0.49) | EGFRPOLBALDH1A1BDKRB1AURKA | |
| SCHEMBL7753196 | 0.81 | ALDH1A1 (0.46) | EGFRPOLBALDH1A1BDKRB1AURKA | |
| SCHEMBL7752068 | 0.81 | BDKRB1 (0.44) | EGFRALDH1A1BDKRB1HPGDSMN1; SMN2 | |
| SCHEMBL7746219 | 0.80 | PPARG (0.44) | EGFRPOLBALDH1A1BDKRB1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686631-B1 | Pyrimidine derivatives and pharmaceutical compositions | KUREHA CHEMICAL IND CO LTD (JP) | 2001-01-17 | — | — | EP | disclosed |
| US-5585381-A | HYPOTENSIVE AGENT AND ALSO TREATING KIDNEY RENAL DISEASE | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1996-12-17 | — | — | US | disclosed |
| EP-0686631-A1 | Pyrimidine derivatives and pharmaceutical composition | Kureha Chemical Industry Co., Ltd. (JP) | 1995-12-13 | — | — | EP | disclosed |