Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | VCP | P55072 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7753196 | 0.94 | ALDH1A1 (0.46) | BDKRB1ALDH1A1EPHX2POLBTDP1 | |
| SCHEMBL7753157 | 0.90 | BDKRB1 (0.53) | BDKRB1ALDH1A1EPHX2POLBTDP1 | |
| SCHEMBL7746219 | 0.90 | PPARG (0.44) | BDKRB1ALDH1A1EPHX2POLBTDP1 | |
| SCHEMBL7752026 | 0.89 | SMN1; SMN2 (0.47) | BDKRB1POLBEGFRHTTHPGD | |
| SCHEMBL7752068 | 0.87 | BDKRB1 (0.44) | BDKRB1ALDH1A1EGFRHDAC3HDAC4 | |
| SCHEMBL7750841 | 0.87 | EGFR (0.52) | BDKRB1ALDH1A1POLBEGFRHDAC3 | |
| SCHEMBL7753138 | 0.85 | LTB4R2 (0.40) | BDKRB1ALDH1A1POLBTDP1EGFR | |
| SCHEMBL7746182 | 0.85 | BDKRB1 (0.49) | BDKRB1ALDH1A1POLBTDP1EGFR | |
| SCHEMBL7750817 | 0.81 | ALDH1A1 (0.52) | BDKRB1ALDH1A1POLBEGFR | |
| SCHEMBL7753170 | 0.81 | GSK3B (0.48) | BDKRB1ALDH1A1POLBEGFRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686631-B1 | Pyrimidine derivatives and pharmaceutical compositions | KUREHA CHEMICAL IND CO LTD (JP) | 2001-01-17 | — | — | EP | disclosed |
| US-5585381-A | HYPOTENSIVE AGENT AND ALSO TREATING KIDNEY RENAL DISEASE | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1996-12-17 | — | — | US | disclosed |
| EP-0686631-A1 | Pyrimidine derivatives and pharmaceutical composition | Kureha Chemical Industry Co., Ltd. (JP) | 1995-12-13 | — | — | EP | disclosed |