Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 9/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | FABP2 | P12104 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6705375 | 0.73 | RIPK1 (0.36) | KMT2AMEN1ACHE | |
| SCHEMBL14723237 | 0.65 | ELANE (0.58) | ELANESRD5A2PPARAKMT2AMAPK1 | |
| SCHEMBL2517350 | 0.64 | KMT2A (0.73) | ELANESRD5A2KMT2AMAPK1LMNA | |
| SCHEMBL8373045 | 0.64 | ELANE (0.53) | ELANESRD5A2PPARAKMT2AMAPK1 | |
| SCHEMBL1952125 | 0.63 | KMT2A (0.59) | SRD5A2KMT2AMAPK1TSHRALDH1A1 | |
| SCHEMBL23373088 | 0.63 | PPARA (0.71) | ELANEPPARAMAPK1PPARGLMNA | |
| SCHEMBL10591230 | 0.63 | ELANE (0.57) | ELANESRD5A2KMT2AMAPK1LMNA | |
| SCHEMBL7416905 | 0.62 | GRN (0.33) | KMT2AMEN1 | |
| SCHEMBL478510 | 0.62 | KMT2A (0.63) | SRD5A2KMT2AMAPK1MAPTTSHR | |
| SCHEMBL10592798 | 0.62 | ELANE (0.47) | ELANESRD5A2KMT2AMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262251-B1 | PRODUCT ANCHORED SEQUENCIAL SYNTHESIS (PASS); AN ANCHOR GROUP ATTACHED TO THE 5' END OF THE GROWING OLIGONUCLEOTIDE PRODUCT ALLOWS THE COUPLED PRODUCT TO BE SEPARATED FROM UNREACTED STARTING MATERIALS | PROLIGO LLC | 2001-07-17 | — | — | US | disclosed |
| EP-0979233-A4 | METHOD FOR SOLUTION PHASE SYNTHESIS OF OLIGONUCLEOTIDES | PROLIGO L L C (US) | 2001-03-21 | — | — | EP | disclosed |
| EP-0979233-A1 | METHOD FOR SOLUTION PHASE SYNTHESIS OF OLIGONUCLEOTIDES | NeXstar Pharmaceuticals, Inc. (US) | 2000-02-16 | — | — | EP | disclosed |
| US-6001966-A | REACTING N-TERMINAL PROTECTED AMINO ACID WITH PEPTIDE STARTING MATERIAL FORMING A PEPTIDE PRODUCT, PARTITIONING FROM UNREACTED MATERIAL AND REAGENTS BASED ON PRESENCE OF N-TERMINAL BLOCKING/ANCHORING GROUP | PROLIGO LLC (US) | 1999-12-14 | — | — | US | disclosed |
| US-5874532-A | USING A N-TERMINAL PROTECTED AMINO ACID MONOMER | NEXSTAR PHARMACEUTICALS, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| WO-1998047910-A1 | METHOD FOR SOLUTION PHASE SYNTHESIS OF OLIGONUCLEOTIDES | PROLIGO LLC (US) | 1998-10-29 | — | — | WO | disclosed |