Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASE1 | P07998 | 1/20 | 0.52 |
| ▸ | TK1 | P04183 | 8/20 | 0.51 |
| ▸ | TK2 | O00142 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8189618 | 1.00 | RNASE1 (0.52) | RNASE1TK1TK2 | |
| SCHEMBL5712028 | 0.94 | RNASE1 (0.47) | RNASE1TK1 | |
| SCHEMBL8903381 | 0.94 | RNASE1 (0.47) | RNASE1TK1 | |
| SCHEMBL10446918 | 0.89 | RNASE1 (0.55) | RNASE1TK1TK2 | |
| SCHEMBL9014404 | 0.89 | RNASE1 (0.55) | RNASE1TK1TK2 | |
| SCHEMBL1727320 | 0.88 | POLB (0.58) | TK1 | |
| SCHEMBL6328992 | 0.88 | RNASE1 (0.52) | RNASE1TK1TK2 | |
| SCHEMBL6328988 | 0.88 | RNASE1 (0.52) | RNASE1TK1TK2 | |
| SCHEMBL6334503 | 0.88 | POLB (0.58) | TK1 | |
| SCHEMBL10446716 | 0.88 | POLB (0.58) | TK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169176-B1 | SYNTHESIZING OLIGONUCLEOTIDES HAVING A BACKBONE OF ALKYL OR ALKOXY THIOUREA LINKAGES; ANTISENSE AND GENE THERAPY AGENTS WITH INCREASED AFFINITY AND NUCLEASE RESISTANCE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-01-02 | — | — | US | disclosed |
| US-6136965-A | Deoxynucleic alkyl and alkoxy thiourea compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-10-24 | — | — | US | disclosed |
| US-6013785-A | Polynucleoside chain having multiple ribonucleosides, the nucleosides coupled by guanidyl linkages | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-01-11 | — | — | US | disclosed |
| US-5932718-A | CONTACTING NUCLEOTIDE OR OLIGONUCLEOTIDE HAVING 5' H-PHOSPHONATE DERIVATIVE WITH 5'-O-TRITYL-3'-AMINO-2'-DEOXYRIBONUCLEOSIDE IN PRESENCE OF OXIDIZING AGENT PRODUCING PROTECTED INTERNUCLEOSIDE LINKAGE | NORTHWESTERN UNIVERSITY (US) | 1999-08-03 | — | — | US | disclosed |
| US-5648480-A | Process for making oligonucleotides having modified internucleoside linkages | NORTHWESTERN UNIVERSITY (US) | 1997-07-15 | — | — | US | disclosed |
| US-5646260-A | PHOSPHORYLATED OLIGONUCLEOTIDES | LETSINGER ROBERT L (US) | 1997-07-08 | — | — | US | disclosed |
| US-5476925-A | Antisense agents | NORTHWESTERN UNIVERSITY (US) | 1995-12-19 | — | — | US | disclosed |