Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7746309 | 1.00 | MAPK1 (0.52) | MAPK1CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL7742216 | 0.90 | CYP1A2 (0.50) | MAPK1CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL7749487 | 0.90 | CYP1A2 (0.50) | MAPK1CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL7747633 | 0.90 | CYP1A2 (0.50) | MAPK1CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL7747870 | 0.89 | NAAA (0.50) | MAPK1CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL7747626 | 0.89 | NAAA (0.50) | MAPK1CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL7746333 | 0.89 | NAAA (0.50) | MAPK1CYP1A2CYP2C19CYP2C9KDM4E | |
| SCHEMBL7742209 | 0.88 | NAAA (0.53) | — | |
| SCHEMBL7742205 | 0.88 | NAAA (0.53) | — | |
| SCHEMBL7746325 | 0.88 | NAAA (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11247976-B2 | Synthetic ligands that modulate the activity of the RhlR quorum sensing receptor | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2022-02-15 | — | — | US | disclosed |
| US-20190144407-A1 | Synthetic Ligands that Modulate the Activity of the RhlR Quorum Sensing Receptor | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-05-16 | — | — | US | disclosed |
| WO-2017190116-A1 | SYNTHETIC LIGANDS THAT MODULATE THE ACTIVITY OF THE RHLR QUORUM SENSING RECEPTOR | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2017-11-02 | — | — | WO | disclosed |
| WO-2001018231-A2 | METHOD FOR PRODUCING (R) OR (S)-HYDROXY-η-BUTYROLACTONE | LONZA AG (CH) | 2001-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144407-A1 | Synthetic Ligands that Modulate the Activity of the RhlR Quorum Sensing Receptor | AREG, QRFPR, GPR139 | MAPK1 2656/4885CYP1A2 3996/4885CYP2C19 3620/4885 |
| US-11247976-B2 | Synthetic ligands that modulate the activity of the RhlR quorum sensing receptor | AREG, QRFPR, GPR139 | MAPK1 2656/4885CYP1A2 3996/4885CYP2C19 3620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.