SCHEMBL7747809

SCHEMBL7747809

O=C(O)CCN(Cc1ccccc1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
HDAC3 O15379 1/20 0.53
MAPK1 P28482 1/20 0.53
ADRA1A P35348 1/20 0.53
HDAC4 P56524 1/20 0.53
SLC6A3 Q01959 1/20 0.53
HDAC1 Q13547 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
HDAC7 Q8WUI4 1/20 0.53
HDAC2 Q92769 1/20 0.53
HDAC10 Q969S8 1/20 0.53
HDAC11 Q96DB2 1/20 0.53
HDAC8 Q9BY41 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
HDAC9 Q9UKV0 1/20 0.53
HDAC5 Q9UQL6 1/20 0.53
REN P00797 2/20 0.53
KEAP1 Q14145 1/20 0.52
LMNA P02545 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1960890 0.85 MAPT (0.62) HDAC3MAPK1ADRA1AHDAC4SLC6A3
SCHEMBL9574969 0.84 HDAC1 (0.49) ALDH1A1NPSR1HDAC3MAPK1ADRA1A
SCHEMBL13472619 0.84 ALDH1A1 (0.54) ALDH1A1NPSR1MAPK1RENLMNA
SCHEMBL23791771 0.84 ALDH1A1 (0.47) ALDH1A1NPSR1HDAC3MAPK1ADRA1A
SCHEMBL12443452 0.83 RECQL (0.54) ALDH1A1NPSR1HDAC3MAPK1ADRA1A
SCHEMBL24325924 0.83 ALDH1A1 (0.46) ALDH1A1NPSR1HDAC3MAPK1ADRA1A
SCHEMBL8966857 0.83 TOP1 (0.47) ALDH1A1NPSR1HDAC3MAPK1ADRA1A
SCHEMBL825414 0.83 LMNA (0.63) ALDH1A1NPSR1HDAC3HDAC1SMN1; SMN2
SCHEMBL19285762 0.82 REN (0.75) ALDH1A1NPSR1HDAC3HDAC1HDAC7
SCHEMBL5146175 0.82 HDAC3 (0.62) ALDH1A1NPSR1HDAC3MAPK1ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1104304-A1 MULTIVALENT AVB3 AND METASTASIS-ASSOCIATED RECEPTOR LIGANDS G.D. SEARLE & CO. (US) 2001-06-06 EP disclosed
EP-1070085-A1 DUAL A v?b 3? AND METASTASIS-ASSOCIATED RECEPTOR LIGANDS G.D. SEARLE & CO. (US) 2001-01-24 EP disclosed
WO-2000009143-A1 MULTIVALENT AVB3 AND METASTASIS-ASSOCIATED RECEPTOR LIGANDS G.D. SEARLE & CO. (US) 2000-02-24 WO disclosed
WO-1999051638-A1 DUAL Avb3 AND METASTASIS-ASSOCIATED RECEPTOR LIGANDS G.D. SEARLE & CO. (US) 1999-10-14 WO disclosed