Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.83 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | PPARD | Q03181 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16127917 | 0.85 | KDM4E (0.78) | RAB9ACYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL13885737 | 0.84 | RAB9A (0.58) | RAB9ACYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL7740936 | 0.84 | HDAC1 (0.64) | RAB9ACYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL28652032 | 0.82 | KCNMA1 (0.60) | RAB9ACYP1A2CYP2D6CYP2C19KCNMA1 | |
| SCHEMBL3528827 | 0.82 | MAPT (0.62) | RAB9ACYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL1091849 | 0.81 | RAB9A (0.68) | RAB9ACYP1A2CYP2D6CYP2C19KDM4E | |
| Fluoride SCHEMBL10885630 | 0.81 | RAB9A (0.68) | RAB9ACYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL28759926 | 0.81 | DHODH (0.63) | RAB9ACYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL29396019 | 0.81 | RAB9A (0.56) | RAB9ACYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL6170575 | 0.81 | POLB (0.67) | RAB9AKDM4EMAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129075-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027820-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2000-05-18 | — | — | WO | disclosed |