SCHEMBL7748808

SCHEMBL7748808

O=C(NC(=O)c1ccccc1Br)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1Cl

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.52
RXFP1 Q9HBX9 1/20 0.47
PYGL P06737 2/20 0.45
NPC1 O15118 1/20 0.44
HPGD P15428 1/20 0.44
RAB9A P51151 1/20 0.44
TRPV1 Q8NER1 1/20 0.42
GPR35 Q9HC97 2/20 0.41
TMPRSS4 Q9NRS4 1/20 0.41
GAA P10253 1/20 0.41
TAS2R14 Q9NYV8 2/20 0.40
KDM4E B2RXH2 1/20 0.40
S1PR1 P21453 1/20 0.40
TP53 P04637 1/20 0.39
GRIK1 P39086 1/20 0.39
F2R P25116 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9119160 0.91 SMN1; SMN2 (0.54) SMN1; SMN2RXFP1PYGLNPC1HPGD
SCHEMBL7752690 0.88 KDM4E (0.53) SMN1; SMN2RXFP1PYGLNPC1HPGD
SCHEMBL7752523 0.87 TRPV1 (0.57) PYGLNPC1HPGDRAB9ATRPV1
SCHEMBL9118302 0.84 KDM4E (0.51) SMN1; SMN2RXFP1PYGLNPC1HPGD
SCHEMBL7748816 0.82 NNMT (0.43) SMN1; SMN2NPC1HPGDRAB9AGPR35
SCHEMBL8013451 0.81 SMN1; SMN2 (0.54) SMN1; SMN2RXFP1PYGLNPC1HPGD
SCHEMBL7748786 0.81 TLR7 (0.49) SMN1; SMN2NPC1GPR35TMPRSS4GAA
SCHEMBL9119083 0.81 TRPV1 (0.51) SMN1; SMN2RXFP1PYGLNPC1HPGD
SCHEMBL29436079 0.79 MEN1 (0.58) NPC1TRPV1GPR35GAAKDM4E
SCHEMBL65405 0.79 MEN1 (0.58) NPC1TRPV1GPR35GAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912502-B1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME DONGBU HANNONG CHEMICAL CO LTD (KR) 2001-01-17 EP claimed
US-6022882-A POTENT GROWTH-RETARDING ACTIVITY AGAINST PESTS DONGBU HANNONG CHEMICAL CO., LTD. (KR) 2000-02-08 US claimed
EP-0912502-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME Hanwha Corporation (KR) 1999-05-06 EP claimed
WO-1998000394-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME HANWHA CORPORATION (KR) 1998-01-08 WO claimed
EP-0912502-B1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME DONGBU HANNONG CHEMICAL CO LTD (KR) 2001-01-17 EP disclosed
US-6022882-A POTENT GROWTH-RETARDING ACTIVITY AGAINST PESTS DONGBU HANNONG CHEMICAL CO., LTD. (KR) 2000-02-08 US disclosed
EP-0912502-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME Hanwha Corporation (KR) 1999-05-06 EP disclosed
WO-1998000394-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME HANWHA CORPORATION (KR) 1998-01-08 WO disclosed