SCHEMBL7748816

SCHEMBL7748816

O=C(NC(=O)c1cccnc1Cl)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NNMT P40261 1/20 0.43
GAA P10253 3/20 0.41
NPC1 O15118 1/20 0.40
GRM4 Q14833 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
S1PR1 P21453 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
GPR35 Q9HC97 1/20 0.40
HTT P42858 2/20 0.39
TMPRSS4 Q9NRS4 1/20 0.39
GFER P55789 1/20 0.39
TUBB4A P04350 1/20 0.39
TUBB P07437 1/20 0.39
TUBA3C P0DPH7 1/20 0.39
TUBA1B P68363 1/20 0.39
TUBA4A P68366 1/20 0.39
TUBB4B P68371 1/20 0.39
TUBB3 Q13509 1/20 0.39
TUBB2A Q13885 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9118561 0.92 NNMT (0.42) NNMTGAANPC1GRM4MEN1
SCHEMBL7752690 0.84 KDM4E (0.53) GAANPC1GRM4MEN1KMT2A
SCHEMBL7752523 0.83 TRPV1 (0.57) GAANPC1MEN1KMT2AGPR35
SCHEMBL7748808 0.82 SMN1; SMN2 (0.52) GAANPC1S1PR1GPR35TMPRSS4
SCHEMBL7748786 0.79 TLR7 (0.49) GAANPC1MEN1KMT2AGPR35
SCHEMBL65405 0.77 MEN1 (0.58) GAANPC1MEN1KMT2AGPR35
SCHEMBL29436079 0.77 MEN1 (0.58) GAANPC1MEN1KMT2AGPR35
SCHEMBL9118302 0.76 KDM4E (0.51) GAANPC1GRM4MEN1KMT2A
SCHEMBL3118093 0.73 BRAF (0.53) NPC1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL10782418 0.73 TRPV1 (0.49) NPC1MEN1KMT2AS1PR1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912502-B1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME DONGBU HANNONG CHEMICAL CO LTD (KR) 2001-01-17 EP claimed
US-6022882-A POTENT GROWTH-RETARDING ACTIVITY AGAINST PESTS DONGBU HANNONG CHEMICAL CO., LTD. (KR) 2000-02-08 US claimed
EP-0912502-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME Hanwha Corporation (KR) 1999-05-06 EP claimed
WO-1998000394-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME HANWHA CORPORATION (KR) 1998-01-08 WO claimed
EP-0912502-B1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME DONGBU HANNONG CHEMICAL CO LTD (KR) 2001-01-17 EP disclosed
US-6022882-A POTENT GROWTH-RETARDING ACTIVITY AGAINST PESTS DONGBU HANNONG CHEMICAL CO., LTD. (KR) 2000-02-08 US disclosed
EP-0912502-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME Hanwha Corporation (KR) 1999-05-06 EP disclosed
WO-1998000394-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME HANWHA CORPORATION (KR) 1998-01-08 WO disclosed