Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | HTR4 | Q13639 | 11/20 | 0.64 |
| ▸ | HTR3A | P46098 | 5/20 | 0.64 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.64 |
| ▸ | HTR3B | O95264 | 3/20 | 0.64 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.64 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.64 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MPO | P05164 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | DRD4 | P21917 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581077 | 0.88 | CTSD (0.59) | GAAHTR4HTR3AHTR3EHTR3B | |
| SCHEMBL14817685 | 0.87 | GAA (0.71) | GAAHTR4HTR3AHTR3EHTR3B | |
| SCHEMBL3963618 | 0.87 | CTSD (0.53) | GAAHTR4HTR3AHTR3EHTR3B | |
| SCHEMBL3102868 | 0.86 | HTR4 (0.70) | GAAHTR4HTR3AHTR3EHTR3B | |
| SCHEMBL7280230 | 0.85 | GAA (0.73) | GAAHTR4HTR3AHTR3EHTR3B | |
| SCHEMBL8247499 | 0.84 | GAA (0.68) | GAAHTR4HTR3AHTR3EHTR3B | |
| SCHEMBL9072065 | 0.84 | GAA (0.50) | GAAHTR4HTR3AHTR3EHTR3B | |
| SCHEMBL22022238 | 0.84 | HTR4 (0.71) | GAAHTR4HTR3AHTR3EHTR3B | |
| SCHEMBL15650650 | 0.84 | HTR4 (0.71) | GAAHTR4HTR3AHTR3EHTR3B | |
| SCHEMBL17069856 | 0.84 | HTR4 (0.64) | GAAHTR4HTR3AHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255319-B1 | ANTISEROTONIN AGENT | SANOFI-SYNTHELABO (FR) | 2001-07-03 | — | — | US | disclosed |
| US-6248757-B1 | ANTISEROTONINE AGENTS | SANOFI-SYNTHELABO (FR) | 2001-06-19 | — | — | US | disclosed |
| CN-1260794-A | 5-aryl-3-(8-azabicyclo (3.2.2) oct-3-yl)-1,3,4-oxadiazol-2(3H)-one derivatives as -5HT4 receptor ligands | SANOFI SYNTHELABO (FR) | 2000-07-19 | — | — | CN | disclosed |