SCHEMBL7752136

SCHEMBL7752136

CC(=O)c1ccc(-c2ccc(C(=O)O)cc2)c(C)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 1/20 0.65
RARB P10826 3/20 0.55
ADH5 P11766 2/20 0.52
RXRA P19793 2/20 0.50
RXRB P28702 1/20 0.50
ALDH1A1 P00352 2/20 0.48
KDM4E B2RXH2 1/20 0.48
GAA P10253 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
MAPT P10636 2/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
SRD5A2 P31213 1/20 0.45
RARG P13631 1/20 0.44
AKR1C3 P42330 2/20 0.44
AKR1C2 P52895 2/20 0.44
FOLH1 Q04609 1/20 0.44
HSD17B10 Q99714 1/20 0.43
MAP4K4 O95819 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2561933 0.93 HSD17B1 (0.70) HSD17B1RARBADH5RXRARXRB
SCHEMBL11507830 0.91 RARB (0.63) HSD17B1RARBADH5RXRARXRB
SCHEMBL14540358 0.89 RARB (0.61) HSD17B1RARBADH5RXRARXRB
SCHEMBL5608472 0.87 HSD17B1 (0.62) HSD17B1RARBADH5ALDH1A1KDM4E
SCHEMBL14947555 0.87 HSD17B1 (0.51) HSD17B1RARBADH5ALDH1A1KDM4E
SCHEMBL31628308 0.87 ADH5 (0.56) HSD17B1RARBADH5RXRARXRB
SCHEMBL4091247 0.86 HSD17B1 (0.81) HSD17B1RARBADH5MAPTNPC1
SCHEMBL25597224 0.86 HSD17B1 (0.60) HSD17B1RARBADH5RXRARXRB
SCHEMBL31084430 0.85 RXRA (0.58) HSD17B1RARBADH5RXRARXRB
SCHEMBL31084426 0.85 RXRA (0.58) HSD17B1RARBADH5RXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
EP-0777650-B1 BIPHENYLAMIDE DERIVATIVES AS 5HT 1D ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2001-03-07 EP disclosed
EP-0799226-B1 TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2001-02-07 EP disclosed
US-5972951-A Tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists SMITHKLINE BEECHAM PLC (GB) 1999-10-26 US disclosed
EP-0752982-B1 BIPHENYL DERIVATIVES AS 5HT1D ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1998-10-14 EP disclosed
US-5817833-A Biphenylamide compounds as 5HT1D Antagonists SMITHKLINE BEECHAM P.L.C. (GB) 1998-10-06 US disclosed
EP-0799226-A1 TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1997-10-08 EP disclosed
EP-0777650-A1 BIPHENYLAMIDE DERIVATIVES AS 5HT 1D? ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1997-06-11 EP disclosed
EP-0752982-A1 BIPHENYL DERIVATIVES AS 5HT1D ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1997-01-15 EP disclosed
WO-1996019477-A1 TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1996-06-27 WO disclosed
WO-1996006079-A1 BIPHENYLAMIDE DERIVATIVES AS 5HT1D ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1996-02-29 WO disclosed
WO-1995026328-A1 BIPHENYL DERIVATIVES AS 5HT1D ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1995-10-05 WO disclosed