SCHEMBL7752264

SCHEMBL7752264

Nc1ccc2c(N)ccc(N)c2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.43
CYP3A4 P08684 5/20 0.43
HPGD P15428 4/20 0.43
TDP1 Q9NUW8 3/20 0.43
TSHR P16473 3/20 0.43
HSD17B10 Q99714 2/20 0.43
CASP1 P29466 3/20 0.42
PARP1 P09874 1/20 0.40
MAPT P10636 5/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
RECQL P46063 3/20 0.39
RAB9A P51151 3/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
NPC1 O15118 2/20 0.39
ALOX15 P16050 2/20 0.39
THRB P10828 2/20 0.39
GFER P55789 1/20 0.39
USP2 O75604 1/20 0.39
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6051251 0.76 TDP1 (0.60) ALDH1A1CYP3A4HPGDTDP1HSD17B10
SCHEMBL20356052 0.76 CASP1 (0.37) ALDH1A1CYP3A4HPGDTDP1TSHR
SCHEMBL4650278 0.75 TTR (0.55) ALDH1A1CYP3A4HPGDTDP1TSHR
SCHEMBL17000438 0.75 TTR (0.55) ALDH1A1CYP3A4HPGDTDP1TSHR
SCHEMBL21974454 0.74 TDP1 (0.62) ALDH1A1CYP3A4HPGDTDP1TSHR
SCHEMBL9231280 0.74 ALDH1A1 (0.54) ALDH1A1CYP3A4HPGDTDP1TSHR
SCHEMBL24254785 0.74 HPRT1 (0.43) ALDH1A1CYP3A4HPGDTDP1HSD17B10
SCHEMBL21499706 0.74 HPRT1 (0.43) ALDH1A1CYP3A4HPGDTDP1HSD17B10
SCHEMBL2023308 0.73 PARP1 (0.41) ALDH1A1CYP3A4HPGDTDP1TSHR
SCHEMBL25990463 0.72 TDP1 (0.39) ALDH1A1CYP3A4HPGDTDP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106232214-B Composite polyamide membrane post-treated with nitrous acid 陶氏环球技术有限责任公司 2021-01-15 CN disclosed
US-10793584-B2 Naphthobischalcogenadiazole derivative and production method therefor OSAKA UNIVERSITY (JP) 2020-10-06 US disclosed
CN-105848758-B Separation of hydrocarbons from aqueous mixtures using fouling resistant reverse osmosis membranes 陶氏环球技术有限责任公司 2020-01-17 CN disclosed
US-20190337966-A1 NAPHTHOBISCHALCOGENADIAZOLE DERIVATIVE AND PRODUCTION METHOD THEREFOR OSAKA UNIVERSITY (JP) 2019-11-07 US disclosed
CN-105848759-B Desalting an aqueous mixture containing nanosized particles using a fouling resistant reverse osmosis membrane 陶氏环球技术有限责任公司 2019-04-02 CN disclosed
EP-3142777-B1 COMPOSITE POLYAMIDE MEMBRANE POST TREATED WITH NITROUS ACID DOW GLOBAL TECHNOLOGIES LLC (US) 2018-10-24 EP disclosed
EP-3092057-B1 TREATMENT OF AQUEOUS MIXTURES CONTAINING ANIONIC SURFACTANTS USING FOULING RESISTANT REVERSE OSMOSIS MEMBRANE DOW GLOBAL TECHNOLOGIES LLC (US) 2018-09-19 EP disclosed
EP-3092056-B1 DESALINATION OF AQUEOUS MIXTURE CONTAINING NANO-SIZED PARTICLES USING FOULING RESISTANT REVERSE OSMOSIS MEMBRANE DOW GLOBAL TECHNOLOGIES LLC (US) 2018-08-01 EP disclosed
WO-2018123207-A1 NAPHTHOBISCHALCOGENADIAZOLE DERIVATIVE AND PRODUCTION METHOD THEREFOR 国立大学法人大阪大学 2018-07-05 WO disclosed
EP-3077088-B1 METHOD FOR FORMING A COMPOSITE POLYAMIDE MEMBRANE POST TREATED WITH NITRIOUS ACID DOW GLOBAL TECHNOLOGIES LLC (US) 2017-12-27 EP disclosed
US-20160304363-A1 SEPARATION OF HYDROCARBONS FROM AQUEOUS MIXTURE USING FOULING RESISTANT REVERSE OSMOSIS MEMBRANE DOW GLOBAL TECHNOLOGIES LLC (US) 2016-10-20 US disclosed
US-20160303516-A1 DESALINATION OF AQUEOUS MIXTURE CONTAINING NANO-SIZED PARTICLES USING FOULING RESISTANT REVERSE OSMOSIS MEMBRANE DOW GLOBAL TECHNOLOGIES LLC (US) 2016-10-20 US disclosed
EP-3077088-A1 COMPOSITE POLYAMIDE MEMBRANE POST TREATED WITH NITRIOUS ACID Dow Global Technologies LLC (US) 2016-10-12 EP disclosed
US-20160271567-A1 COMPOSITE POLYAMIDE MEMBRANE POST TREATED WITH NITRIOUS ACID THE DOW CHEMICAL COMPANY 2016-09-22 US disclosed
CN-105848759-A Desalting an aqueous mixture containing nanosized particles using a fouling resistant reverse osmosis membrane 陶氏环球技术有限责任公司 2016-08-10 CN disclosed
CN-105848758-A Separation of hydrocarbons from aqueous mixtures using fouling resistant reverse osmosis membranes 陶氏环球技术有限责任公司 2016-08-10 CN disclosed
WO-2015175256-A1 COMPOSITE POLYAMIDE MEMBRANE POST TREATED WITH NITROUS ACID DOW GLOBAL TECHNOLOGIES LLC (US) 2015-11-19 WO disclosed
EP-0710684-B1 Preparation process of polyhydroxycarboxylic acid MITSUI CHEMICALS INC (JP) 2001-01-31 EP disclosed
US-5770683-A Preparation process of polyhydroxycarboxylic acid MITSUI TOATSU CHEMICALS, INC. (JP) 1998-06-23 US disclosed
EP-0710684-A2 Preparation process of polyhydroxycarboxylic acid MITSUI TOATSU CHEMICALS, Inc. (JP) 1996-05-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10793584-B2 Naphthobischalcogenadiazole derivative and production method therefor CYP24A1, CYP26B1, CYP21A2 ALDH1A1 600/4885CYP3A4 389/4885HPGD 815/4885
US-20190337966-A1 NAPHTHOBISCHALCOGENADIAZOLE DERIVATIVE AND PRODUCTION METHOD THEREFOR CYP24A1, CYP26B1, CYP21A2 ALDH1A1 600/4885CYP3A4 389/4885HPGD 815/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.