Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | APP | P05067 | 3/20 | 0.51 |
| ▸ | TTR | P02766 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | DPP4 | P27487 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15981545 | 0.80 | IAPP (0.66) | IAPPPTGS1APPTTRKDM4E | |
| SCHEMBL29345014 | 0.80 | IAPP (0.66) | IAPPPTGS1APPTTRKDM4E | |
| SCHEMBL8365088 | 0.79 | IAPP (0.64) | IAPPPTGS1APPTTRKDM4E | |
| SCHEMBL19088711 | 0.77 | IAPP (0.66) | IAPPPTGS1APPTTRKDM4E | |
| SCHEMBL6378408 | 0.75 | APP (0.53) | IAPPPTGS1APPTTRKDM4E | |
| SCHEMBL1881133 | 0.74 | IAPP (1.00) | IAPPPTGS1APPTTRKDM4E | |
| SCHEMBL1881134 | 0.74 | IAPP (1.00) | IAPPPTGS1APPTTRKDM4E | |
| SCHEMBL29364807 | 0.74 | IAPP (1.00) | IAPPPTGS1APPTTRKDM4E | |
| SCHEMBL28825240 | 0.74 | HSD17B10 (0.55) | IAPPPTGS1APPTTRKDM4E | |
| SCHEMBL23854648 | 0.74 | HSD17B10 (0.64) | IAPPPTGS1APPTTRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1063888-A1 | NOVEL HIV INTEGRASE INHIBITORS AND HIV THERAPY BASED ON DRUG COMBINATIONS INCLUDING INTEGRASE INHIBITORS | The Regents of the University of California (US) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999048371-A1 | NOVEL HIV INTEGRASE INHIBITORS AND HIV THERAPY BASED ON DRUG COMBINATIONS INCLUDING INTEGRASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-09-30 | — | — | WO | disclosed |