Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.56 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10598787 | 0.88 | MAPT (0.66) | MAPTCYP1A2CYP2C9CYP2C19HDAC1 | |
| SCHEMBL6812211 | 0.86 | CASP1 (0.57) | MAPTCYP1A2CYP2C9CYP2C19HDAC1 | |
| SCHEMBL6816538 | 0.86 | MAPT (0.54) | MAPTCYP1A2CYP2C9CYP2C19HDAC1 | |
| SCHEMBL7753930 | 0.85 | MAPT (0.50) | MAPTCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5381695 | 0.84 | MAPT (0.72) | MAPTLTC4SSERPINE1MEN1KMT2A | |
| SCHEMBL31541226 | 0.84 | MAPT (0.58) | MAPTCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL6545922 | 0.82 | MAPT (0.48) | MAPTCYP1A2CYP2C9CYP2C19HDAC1 | |
| SCHEMBL11591501 | 0.82 | HDAC1 (0.71) | MAPTCYP1A2CYP2C9CYP2C19HDAC1 | |
| SCHEMBL1615339 | 0.82 | MAPT (0.58) | MAPTCYP1A2CYP2C9CYP2C19HDAC1 | |
| SCHEMBL6546897 | 0.81 | MEN1 (0.52) | MEN1KMT2AALDH1A1MAPK1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068176-A1 | CYSTEINE AMIDES AS FARNESYL TRANSFERASE INHIBITORS | Jomaa, Hassan (DE) | 2001-01-17 | — | — | EP | disclosed |
| WO-2000027803-A1 | CYSTEINE AMIDES AS FARNESYL TRANSFERASE INHIBITORS | JOMAA, HASSAN (DE) | 2000-05-18 | — | — | WO | disclosed |