SCHEMBL7753097

SCHEMBL7753097

NCCc1c(Cc2ccc(Cl)cc2)[nH]c2ccccc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.48
CYP3A4 P08684 2/20 0.48
HPGD P15428 2/20 0.48
TSHR P16473 2/20 0.48
CYP2C19 P33261 2/20 0.48
MTNR1A P48039 2/20 0.48
MTNR1B P49286 2/20 0.48
TDP1 Q9NUW8 2/20 0.48
MEN1 O00255 1/20 0.48
CYP2C9 P11712 1/20 0.48
KMT2A Q03164 1/20 0.48
MAPT P10636 4/20 0.47
PRNP P04156 1/20 0.47
MC4R P32245 5/20 0.45
MC5R P33032 5/20 0.45
MC3R P41968 5/20 0.45
KDM4E B2RXH2 1/20 0.44
TAAR1 Q96RJ0 1/20 0.43
ALDH1A1 P00352 1/20 0.43
CYP2D6 P10635 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8804026 0.88 MTNR1A (0.59) CYP1A2CYP3A4HPGDTSHRCYP2C19
SCHEMBL7752754 0.81 TAAR1 (0.51) CYP1A2CYP3A4HPGDTSHRCYP2C19
SCHEMBL7698484 0.78 MAPT (0.54) CYP1A2CYP3A4HPGDTSHRCYP2C19
SCHEMBL14074161 0.78 HTR2A (0.63) MAPTKDM4EHTR6DRD2HTR2A
SCHEMBL6993933 0.77 MAPT (0.49) CYP1A2CYP3A4HPGDTSHRCYP2C19
SCHEMBL8805387 0.76 MTNR1A (0.48) CYP1A2CYP3A4HPGDTSHRCYP2C19
SCHEMBL3886866 0.75 HTR6 (0.63) CYP1A2CYP3A4HPGDTSHRCYP2C19
SCHEMBL27683744 0.75 HTR6 (0.50) CYP1A2CYP3A4HPGDTSHRCYP2C19
SCHEMBL27962585 0.75 HTR6 (0.49) CYP1A2CYP3A4TSHRMEN1KMT2A
SCHEMBL8986642 0.74 CHRNB2 (0.43) CYP1A2CYP3A4HPGDTSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1071664-A1 SUBSTITUTED 2-OXO-ALKANOIC ACID- 2-(INDOL-3-YL)-ETHYL] AMIDES BAYER AG (DE) 2001-01-31 EP disclosed
WO-1999054301-A1 SUBSTITUTED 2-OXO-ALKANOIC ACID-[2-(INDOL-3-YL)-ETHYL] AMIDES BAYER AKTIENGESELLSCHAFT (DE) 1999-10-28 WO disclosed
EP-0623138-A1 NEW ADENOSINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. UNION PHARMA SCIENT APPL (FR) 1994-11-09 EP disclosed