Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 3/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7753134 | 1.00 | P2RX4 (0.44) | P2RX4BCHEALDH1A1PDE4BDAGLA | |
| SCHEMBL12114585 | 0.87 | POLB (0.43) | ALDH1A1PDE4BHSD11B1CNR1 | |
| SCHEMBL12115975 | 0.87 | PDE4B (0.40) | P2RX4ALDH1A1PDE4BHSD11B1MAPK14 | |
| SCHEMBL12115988 | 0.86 | P2RX4 (0.48) | P2RX4BCHEALDH1A1PDE4BHSD11B1 | |
| SCHEMBL8464658 | 0.85 | P2RX4 (0.48) | P2RX4BCHEALDH1A1PDE4BHSD11B1 | |
| SCHEMBL8464656 | 0.85 | P2RX4 (0.48) | P2RX4BCHEALDH1A1PDE4BHSD11B1 | |
| SCHEMBL12115979 | 0.84 | P2RX4 (0.40) | P2RX4BCHEALDH1A1PDE4BHSD11B1 | |
| SCHEMBL12115401 | 0.83 | NPC1 (0.43) | HSD11B1CNR1 | |
| SCHEMBL8467359 | 0.83 | P2RX4 (0.50) | P2RX4BCHEALDH1A1PDE4BHSD11B1 | |
| SCHEMBL12114598 | 0.83 | ALDH1A1 (0.43) | P2RX4ALDH1A1PDE4BHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170119734-A1 | TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE | INFINITY PHARMACEUTICALS, INC. | 2017-05-04 | — | — | US | disclosed |
| US-9346769-B2 | Tetrazolones as inhibitors of fatty acid synthase | INFINITY PHARMACEUTICALS, INC. (US) | 2016-05-24 | — | — | US | disclosed |
| US-20140079667-A1 | TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE | INFINITY PHARMACEUTICALS, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-8546432-B2 | Tetrazolones as inhibitors of fatty acid synthase | INFINITY PHARMACEUTICALS, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20110274655-A1 | TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE | Infinity Pharmaceuticals (US) | 2011-11-10 | — | — | US | disclosed |
| WO-2001039595-A2 | METHOD FOR INCREASING THE YIELD OF CROPS | NIHON BAYER AGROCHEM K.K. (DE) | 2001-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110274655-A1 | TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE | FASN, ACSL1, HSD17B12 | P2RX4 4589/4885BCHE 3011/4885ALDH1A1 213/4885 |
| US-20170119734-A1 | TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE | FASN, ACSL1, HSD17B12 | P2RX4 4590/4885BCHE 2942/4885ALDH1A1 220/4885 |
| US-20140079667-A1 | TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE | FASN, ACSL1, HSD17B12 | P2RX4 4589/4885BCHE 3011/4885ALDH1A1 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.