Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2431069 | 0.80 | SIGMAR1 (0.55) | SIGMAR1KDM4EGAACYP1A2HPGD | |
| SCHEMBL28864374 | 0.77 | SIGMAR1 (0.54) | SIGMAR1CYP1A2HPGDALDH1A1TSHR | |
| SCHEMBL28317409 | 0.76 | SIGMAR1 (0.50) | SIGMAR1KDM4EGAAHPGDALDH1A1 | |
| SCHEMBL3068495 | 0.74 | SIGMAR1 (0.49) | SIGMAR1KDM4EGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL28238304 | 0.74 | SIGMAR1 (0.47) | SIGMAR1CYP1A2HPGDALDH1A1TSHR | |
| SCHEMBL6831348 | 0.73 | SIGMAR1 (0.47) | SIGMAR1KDM4EGAAALDH1A1TDP1 | |
| SCHEMBL30176884 | 0.73 | SIGMAR1 (0.47) | SIGMAR1KDM4EGAACYP1A2HPGD | |
| SCHEMBL2379010 | 0.73 | SIGMAR1 (0.47) | SIGMAR1KDM4EGAACYP1A2HPGD | |
| SCHEMBL17710565 | 0.71 | SIGMAR1 (0.64) | SIGMAR1CYP1A2HPGDALDH1A1TSHR | |
| SCHEMBL2575466 | 0.71 | SIGMAR1 (0.53) | SIGMAR1KDM4EGAACYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071414-A1 | COMPOUNDS AND METHODS FOR TREATING MITOCHONDRIA-ASSOCIATED DISEASES | Mitokor (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999055321-A1 | COMPOUNDS AND METHODS FOR TREATING MITOCHONDRIA-ASSOCIATED DISEASES | MITOKOR (US) | 1999-11-04 | — | — | WO | disclosed |