SCHEMBL7754182

SCHEMBL7754182

[c]1nc2c(-c3cccc4ccccc34)cccc2s1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.37
ALDH1A1 P00352 4/20 0.37
HPGD P15428 4/20 0.37
HSD17B10 Q99714 3/20 0.37
TSHR P16473 2/20 0.37
MAPK1 P28482 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
TP53 P04637 1/20 0.37
MAPT P10636 1/20 0.37
NFKB1 P19838 1/20 0.37
NFKB2 Q00653 1/20 0.37
RELA Q04206 1/20 0.37
ATM Q13315 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ALOX15 P16050 4/20 0.35
NISCH Q9Y2I1 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
RAB9A P51151 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10411212 0.86
SCHEMBL7670367 0.82 MAPT (0.40) KDM4EALDH1A1HPGDHSD17B10TSHR
SCHEMBL15415250 0.79 ENPP3 (0.31) KDM4EALDH1A1HPGDHSD17B10TSHR
SCHEMBL2516601 0.79 HSD17B10 (0.41) KDM4EALDH1A1HPGDHSD17B10TSHR
SCHEMBL4337978 0.79 LIMK1 (0.39) ALDH1A1HPGDHSD17B10MAPK1TNF
SCHEMBL2679046 0.78 KDM4E (0.40) KDM4EALDH1A1HSD17B10MAPT
SCHEMBL5834328 0.76 PARP14 (0.43) MAPTMEN1KMT2ARAB9A
SCHEMBL16563088 0.74 KDM4E (0.30) KDM4EALDH1A1HSD17B10MAPT
SCHEMBL290970 0.74 ESR1 (0.43) KDM4EALDH1A1HPGDHSD17B10TSHR
SCHEMBL1404094 0.73 RAB9A (0.45) KDM4EALDH1A1HPGDHSD17B10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8852755-B2 Oxadiazole metallic complexes and their electronic and opto-electronic applications MERCK PATENT GMBH (DE) 2014-10-07 US claimed
CN-104629731-B Organic compound and the application in electroluminescent device thereof 吉林奥来德光电材料股份有限公司 2016-09-07 CN disclosed
CN-104629731-A Organic compound and applications of organic compound in electroluminescent devices JILIN OPTICAL & ELECTRONIC MATERIALS CO LTD 2015-05-20 CN disclosed
EP-0803506-B1 PROCESS FOR THE PREPARATION OF 3-HALOGENOCEPHEM DERIVATIVES OTSUKA KAGAKU KK (JP) 2001-03-14 EP disclosed