Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8393177 | 0.86 | TLR9 (0.51) | MAPTALDH1A1KMT2ALMNAHTT | |
| SCHEMBL10632279 | 0.86 | PTGES (0.52) | MAPTALDH1A1KMT2ALMNANPSR1 | |
| SCHEMBL10632277 | 0.86 | PTGES (0.52) | MAPTALDH1A1KMT2ALMNANPSR1 | |
| SCHEMBL7756152 | 0.79 | CYP1A2 (0.56) | MAPTALDH1A1KMT2APOLBHTT | |
| SCHEMBL429369 | 0.79 | ALDH1A1 (0.47) | MAPTALDH1A1LMNANPSR1POLB | |
| SCHEMBL16959289 | 0.79 | MAPT (0.54) | MAPTALDH1A1KMT2ALMNANPSR1 | |
| SCHEMBL5578163 | 0.78 | ALDH1A1 (0.51) | MAPTALDH1A1LMNANPSR1MAOB | |
| SCHEMBL24215128 | 0.78 | MAPT (0.47) | MAPTALDH1A1KMT2ALMNANPSR1 | |
| SCHEMBL4998777 | 0.77 | MAPT (0.56) | MAPTALDH1A1KMT2ALMNANPSR1 | |
| SCHEMBL16955204 | 0.76 | MAPT (0.54) | MAPTALDH1A1KMT2ALMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777650-B1 | BIPHENYLAMIDE DERIVATIVES AS 5HT 1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-03-07 | — | — | EP | disclosed |
| US-5817833-A | Biphenylamide compounds as 5HT1D Antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-10-06 | — | — | US | disclosed |
| EP-0777650-A1 | BIPHENYLAMIDE DERIVATIVES AS 5HT 1D? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996006079-A1 | BIPHENYLAMIDE DERIVATIVES AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-02-29 | — | — | WO | disclosed |