Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.51 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 6/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TYR | P14679 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287155 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2PLA2G2APLA2G5PPARGPPARA | |
| SCHEMBL509967 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2PLA2G2APLA2G5PPARGPPARA | |
| SCHEMBL8467616 | 0.95 | SMN1; SMN2 (0.55) | SMN1; SMN2PLA2G2APLA2G5PPARGPPARA | |
| SCHEMBL8466581 | 0.95 | SMN1; SMN2 (0.55) | SMN1; SMN2PLA2G2APLA2G5PPARGPPARA | |
| SCHEMBL9828390 | 0.95 | SMN1; SMN2 (0.55) | SMN1; SMN2PLA2G2APLA2G5PPARGPPARA | |
| SCHEMBL10481485 | 0.94 | SMN1; SMN2 (0.48) | SMN1; SMN2PLA2G2APLA2G5PPARGPPARA | |
| SCHEMBL10481483 | 0.94 | SMN1; SMN2 (0.48) | SMN1; SMN2PLA2G2APLA2G5PPARGPPARA | |
| SCHEMBL7770760 | 0.93 | PLA2G2A (0.56) | SMN1; SMN2PLA2G2APLA2G5PPARGPPARA | |
| SCHEMBL7770749 | 0.93 | PLA2G2A (0.56) | SMN1; SMN2PLA2G2APLA2G5PPARGPPARA | |
| SCHEMBL7770751 | 0.93 | PLA2G2A (0.56) | SMN1; SMN2PLA2G2APLA2G5PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3265448-A1 | RILUZOLE PRODRUGS AND THEIR USE | Biohaven Pharmaceutical Holding Company Ltd. (US) | 2018-01-10 | — | — | EP | disclosed |
| WO-2016140879-A9 | RILUZOLE PRODRUGS AND THEIR USE | BIOHAVEN PHARMACEUTICAL HOLDING COMPANY LTD. (US) | 2016-11-03 | — | — | WO | disclosed |
| WO-2016140878-A9 | PRODRUGS RILUZOLE AND THEIR METHOD OF USE | BIOHAVEN PHARMACEUTICAL HOLDING COMPANY LTD. (US) | 2016-10-20 | — | — | WO | disclosed |
| EP-1087935-A1 | ANTHRACENE DERIVATIVES AS ANTI-CANCER AGENTS | BTG INTERNATIONAL LIMITED (GB) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065866-A1 | ANTHRACENE DERIVATIVES AS ANTI-CANCER AGENTS | BTG INTERNATIONAL LIMITED (GB) | 1999-12-23 | — | — | WO | disclosed |