Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10913571 | 0.78 | KDM4E (0.54) | KDM4EADORA3ADORA2AADORA1KMT2A | |
| SCHEMBL6665512 | 0.74 | ADORA1 (0.47) | KDM4EADORA3ADORA2AADORA1KMT2A | |
| SCHEMBL2053931 | 0.72 | KDM4E (0.48) | KDM4EADORA3ADORA2AADORA1KMT2A | |
| SCHEMBL6256195 | 0.70 | KDM4E (0.57) | KDM4EKMT2AMEN1ESR1ESR2 | |
| SCHEMBL10505618 | 0.70 | ENPP1 (0.44) | KDM4EENPP1LMNAPOLBADORA3 | |
| SCHEMBL5815474 | 0.70 | TNKS (0.43) | KDM4EENPP1POLBKMT2AMEN1 | |
| SCHEMBL18131793 | 0.70 | MEN1 (0.48) | KDM4EKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL2274802 | 0.70 | KDM4E (0.49) | KDM4ELMNAADORA3ADORA2AADORA1 | |
| SCHEMBL3246323 | 0.68 | METAP2 (0.56) | KDM4EKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL4164854 | 0.68 | ESR1 (0.47) | ENPP1ESR1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087790-A2 | USE OF A COMPOUND HAVING AFFINITY FOR THE BENZODIAZEPINE MITOCHONDRIAL RECEPTOR IN CANCER THERAPY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999066958-A2 | USE OF A COMPOUND HAVING AFFINITY FOR THE BENZODIAZEPINE MITOCHONDRIAL RECEPTOR IN CANCER THERAPY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1999-12-29 | — | — | WO | disclosed |
| EP-0210084-B1 | AMIDES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | RHONE-POULENC SANTE (FR) | 1989-02-08 | — | — | EP | disclosed |
| EP-0210084-A1 | Amides, processes for their preparation and medicaments containing them | RHONE-POULENC SANTE (FR) | 1987-01-28 | — | — | EP | disclosed |