Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10913571 | 0.84 | KDM4E (0.54) | KDM4EMETAP2KMT2AL3MBTL1IDO1 | |
| SCHEMBL27610258 | 0.80 | TSHR (0.45) | KDM4ETSHRMMP2CHRM1COMT | |
| SCHEMBL6665512 | 0.76 | ADORA1 (0.47) | KDM4EKMT2ANPC1L3MBTL1ADORA3 | |
| SCHEMBL27703790 | 0.76 | KDM4E (0.47) | KDM4ETSHRMMP2CHRM1COMT | |
| Oxyquinoline SCHEMBL28769239 | 0.75 | TSHR (0.68) | KDM4ETSHRMMP2CHRM1COMT | |
| SCHEMBL12763641 | 0.74 | KDM4E (0.49) | KDM4ETSHRMETAP1LMNANPC1 | |
| SCHEMBL6256195 | 0.74 | KDM4E (0.57) | KDM4ETSHRMMP2CHRM1COMT | |
| SCHEMBL8055697 | 0.73 | ACHE (0.55) | KDM4ETSHRMMP2CHRM1COMT | |
| SCHEMBL30525703 | 0.72 | ALDH1A1 (0.50) | KDM4EMETAP1LMNAKMT2ATP53 | |
| SCHEMBL12914229 | 0.72 | TGFBR1 (0.49) | KDM4ETSHRMETAP1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130121959-A1 | IL-22-FC AND HEPCIDIN ACTIVITY | AMGEN INC. | 2013-05-16 | — | — | US | disclosed |
| EP-2523689-A1 | IL-22-FC AND HEPCIDIN ACTIVITY | Amgen Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011087986-A1 | IL-22-FC AND HEPCIDIN ACTIVITY | AMGEN INC. (US) | 2011-07-21 | — | — | WO | disclosed |