Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | FSHR | P23945 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6653711 | 0.88 | OPRM1 (0.47) | OPRM1OPRK1BRD4KMT2AALDH1A1 | |
| SCHEMBL6653714 | 0.88 | OPRM1 (0.47) | OPRM1OPRK1BRD4KMT2AALDH1A1 | |
| SCHEMBL7757867 | 0.85 | OPRM1 (0.44) | OPRM1OPRK1BRD4KMT2ANPC1 | |
| SCHEMBL6656375 | 0.85 | OPRM1 (0.44) | OPRM1OPRK1BRD4KMT2ANPC1 | |
| SCHEMBL7756051 | 0.85 | OPRM1 (0.44) | OPRM1OPRK1BRD4KMT2ANPC1 | |
| SCHEMBL6659963 | 0.83 | OPRM1 (0.43) | OPRM1OPRK1BRD4ALDH1A1 | |
| SCHEMBL6659961 | 0.83 | OPRM1 (0.43) | OPRM1OPRK1BRD4ALDH1A1 | |
| SCHEMBL7754596 | 0.77 | PKM (0.45) | OPRM1HDAC1KMT2AHPGDALDH1A1 | |
| SCHEMBL7755278 | 0.77 | OPRM1 (0.36) | OPRM1OPRK1 | |
| SCHEMBL6527559 | 0.76 | OPRM1 (0.39) | OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077940-A1 | 4-PHENYLPIPERIDINES FOR THE TREATMENT OF PRURITIC DERMATOSES | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059971-A1 | NOVEL 4-PHENYLPIPERIDINES FOR THE TREATMENT OF PRURITIC DERMATOSES | PFIZER INC. (US) | 1999-11-25 | — | — | WO | disclosed |