Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.59 |
| ▸ | CDK1 | P06493 | 2/20 | 0.55 |
| ▸ | CDK4 | P11802 | 2/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.55 |
| ▸ | CCND1 | P24385 | 2/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812882 | 0.97 | PDGFRB (0.57) | PDGFRBPDGFRACDK1CDK4CCNB1 | |
| SCHEMBL5309393 | 0.90 | RIPK2 (0.57) | PDGFRBPDGFRACDK1CDK4CCNB1 | |
| Hydrochloric Acid SCHEMBL28182948 | 0.88 | CDK4 (0.50) | PDGFRBPDGFRACDK1CDK4CCNB1 | |
| SCHEMBL7801861 | 0.86 | KDM4E (0.55) | PDGFRBPDGFRACDK2EGFRKDR | |
| SCHEMBL360021 | 0.86 | EGFR (0.53) | PDGFRBPDGFRAEGFRRETKDR | |
| Hydrochloric Acid SCHEMBL8809017 | 0.85 | PDGFRB (0.62) | PDGFRBPDGFRACDK1CDK4CCNB1 | |
| SCHEMBL7753469 | 0.85 | FGFR1 (0.56) | PDGFRBPDGFRACDK2EGFRRET | |
| SCHEMBL7799220 | 0.85 | ABCG2 (0.65) | CDK1EGFRKDRKDM4EMAPT | |
| SCHEMBL7800405 | 0.85 | EGFR (0.56) | PDGFRBPDGFRACDK1CDK4CCNB1 | |
| SCHEMBL28221880 | 0.85 | PDGFRB (0.64) | PDGFRBPDGFRAEGFRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082311-A1 | QUINAZOLINES FOR TREATING BRAIN TUMOR | Parker Hughes Institute (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999061428-A1 | QUINAZOLINES FOR TREATING BRAIN TUMOR | PARKER HUGHES INSTITUTE (US) | 1999-12-02 | — | — | WO | disclosed |