Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.56 |
| ▸ | FLT1 | P17948 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.56 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.56 |
| ▸ | KIF5B | P33176 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 7/20 | 0.55 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360021 | 0.85 | EGFR (0.53) | RETKDRSYKEGFRBRAF | |
| SCHEMBL7757002 | 0.85 | PDGFRB (0.59) | RETCDK2KDREGFRBRAF | |
| SCHEMBL7800405 | 0.85 | EGFR (0.56) | CDK2SYKEGFRERBB2ABCG2 | |
| SCHEMBL28221880 | 0.85 | PDGFRB (0.64) | SYKEGFRERBB2ABCG2RAF1 | |
| SCHEMBL7799220 | 0.85 | ABCG2 (0.65) | EPHB2KDREGFRERBB2ABCG2 | |
| SCHEMBL8812882 | 0.83 | PDGFRB (0.57) | RETCDK2KDREGFRBRAF | |
| SCHEMBL7801689 | 0.81 | ABCG2 (0.67) | EGFRERBB2ABCG2RAF1BRAF | |
| SCHEMBL1246693 | 0.80 | ABCG2 (0.58) | RETCDK2KIF5BKDREGFR | |
| SCHEMBL7801622 | 0.80 | SYK (0.60) | CDK2SYKEGFRABCG2BRAF | |
| Hydrochloric Acid SCHEMBL28182948 | 0.80 | CDK4 (0.50) | RETCDK2KDREGFRRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999061428-A9 | QUINAZOLINES FOR TREATING BRAIN TUMOR | PARKER HUGHES INST (US) | 2001-10-04 | — | — | WO | disclosed |
| WO-2001045641-A2 | INHIBITORS OF THROMBIN INDUCED PLATELET AGGREGATION | PARKER HUGHES INSTITUTE (US) | 2001-06-28 | — | — | WO | disclosed |
| WO-2001035952-A2 | RADIOSENSITIZATION OF HUMAN GLIOBLASTOMA CELLS BY QUINAZOLINE COMPOUNDS | PARKER HUGUES INSTITUTE (US) | 2001-05-25 | — | — | WO | disclosed |
| EP-1082311-A1 | QUINAZOLINES FOR TREATING BRAIN TUMOR | Parker Hughes Institute (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999061428-A1 | QUINAZOLINES FOR TREATING BRAIN TUMOR | PARKER HUGHES INSTITUTE (US) | 1999-12-02 | — | — | WO | disclosed |