Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.65 |
| ▸ | EGFR | P00533 | 14/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.56 |
| ▸ | GAK | O14976 | 3/20 | 0.56 |
| ▸ | FBP1 | P09467 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7524075 | 0.90 | ABCG2 (0.54) | ABCG2EGFRERBB2GAKFBP1 | |
| SCHEMBL5909044 | 0.88 | FBP1 (0.58) | ABCG2EGFRERBB2GAKFBP1 | |
| SCHEMBL7757002 | 0.85 | PDGFRB (0.59) | EGFRKDRKDM4ECDK1MAPT | |
| SCHEMBL7753469 | 0.85 | FGFR1 (0.56) | ABCG2EGFRERBB2KDRMAPT | |
| SCHEMBL28221880 | 0.85 | PDGFRB (0.64) | ABCG2EGFRERBB2FBP1TNF | |
| SCHEMBL7800405 | 0.85 | EGFR (0.56) | ABCG2EGFRERBB2FBP1KDM4E | |
| SCHEMBL8812882 | 0.83 | PDGFRB (0.57) | EGFRKDRKDM4ECDK1MAPT | |
| SCHEMBL7801689 | 0.81 | ABCG2 (0.67) | ABCG2EGFRERBB2KDM4EMAPT | |
| SCHEMBL7754110 | 0.81 | EGFR (0.54) | ABCG2EGFRERBB2KDRKDM4E | |
| SCHEMBL1246693 | 0.80 | ABCG2 (0.58) | ABCG2EGFRERBB2KDRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1162974-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056338-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |