Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7757002 | 0.85 | PDGFRB (0.59) | EGFRMAPTPDGFRBPDGFRAKDM4E | |
| SCHEMBL7753469 | 0.85 | FGFR1 (0.56) | EGFRABCG2TP53MAPTPOLB | |
| SCHEMBL28221880 | 0.85 | PDGFRB (0.64) | EGFRABCG2TP53MAPTPDGFRB | |
| SCHEMBL7799220 | 0.85 | ABCG2 (0.65) | EGFRABCG2MAPTKDM4EFBP1 | |
| SCHEMBL8812882 | 0.83 | PDGFRB (0.57) | EGFRTP53MAPTPOLBPDGFRB | |
| SCHEMBL7801689 | 0.81 | ABCG2 (0.67) | EGFRABCG2MAPTKDM4EERBB2 | |
| SCHEMBL7801622 | 0.80 | SYK (0.60) | EGFRABCG2SYKCDK2USP2 | |
| SCHEMBL27565491 | 0.79 | KDM4E (0.49) | ABCG2TP53MAPTPOLBPDGFRB | |
| SCHEMBL4587365 | 0.78 | MAP3K5 (0.61) | EGFRABCG2SYKMAP3K5 | |
| SCHEMBL7791014 | 0.78 | C1R (0.51) | EGFRMAPTPDGFRBPDGFRAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1162974-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-1163228-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056338-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |
| WO-2000056720-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |