Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 10/20 | 0.75 |
| ▸ | PSMB5 | P28074 | 10/20 | 0.75 |
| ▸ | PSMB2 | P49721 | 8/20 | 0.75 |
| ▸ | LTA4H | P09960 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10827750 | 0.98 | PSMB1 (0.78) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL6597214 | 0.87 | PSMB1 (0.97) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL6442924 | 0.86 | PSMB1 (0.77) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| Hydrochloric Acid SCHEMBL227699 | 0.84 | PSMB1 (0.75) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL1027972 | 0.84 | PSMB1 (0.80) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL3026592 | 0.84 | PSMB1 (0.75) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL2741667 | 0.84 | PSMB1 (0.80) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL6534752 | 0.84 | KDM4E (0.77) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL5685572 | 0.84 | PSMB1 (0.75) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL12193816 | 0.83 | KDM4E (0.80) | PSMB1PSMB5PSMB2LTA4HKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0693488-B1 | An improved process for preparing 3-(4-aminoethoxy-benzoyl)benzo beta -thiophenes | LILLY CO ELI (US) | 2001-09-19 | — | — | EP | disclosed |
| EP-0765321-B1 | 2-AMINO-3-AROYL-BENZO BETA THIOPHENES AND METHOD OF MAKING THE SAME | LILLY CO ELI (US) | 2001-04-18 | — | — | EP | disclosed |
| EP-0764150-B1 | PRODUCTION OF HYDROXYTHIOACETAMIDES AND USE THEREOF IN THE SYNTHESIS OF BENZOTHIOPHENES | LILLY CO ELI (US) | 1999-10-27 | — | — | EP | disclosed |
| US-5792870-A | 2-amino-3-aroyl-benzo β!thiophenes and methods for preparing and using same to produce 6-hdyroxy-2-(4-hydroxyphenyl)-3- 4-(2-aminoethoxy)-benzoyl!benzo β!thiophenes | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0764150-A4 | PRODUCTION OF HYDROXYTHIOACETAMIDES AND USE THEREOF IN THE SYNTHESIS OF BENZOTHIOPHENES | LILLY CO ELI (US) | 1997-09-10 | — | — | EP | disclosed |
| EP-0765321-A4 | — | — | 1997-05-02 | — | — | EP | disclosed |
| EP-0765321-A1 | 2-AMINO-3-AROYL-BENZO BETA THIOPHENES AND METHOD OF MAKING THE SAME | ELI LILLY AND COMPANY (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0764150-A1 | PRODUCTION OF HYDROXYTHIOACETAMIDES AND USE THEREOF IN THE SYNTHESIS OF BENZOTHIOPHENES | ELI LILLY AND COMPANY (US) | 1997-03-26 | — | — | EP | disclosed |
| US-5554755-A | 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes | ELI LILLY AND COMPANY (US) | 1996-09-10 | — | — | US | disclosed |
| US-5523416-A | Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| US-5512684-A | Process for preparing 3-(4-aminoethoxy-benzoyl) benzo B!-thiophenes | ELI LILLY AND COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0693488-A1 | An improved process for preparing 3-(4-aminoethoxy-benzoyl)benzo beta -thiophenes | ELI LILLY AND COMPANY (US) | 1996-01-24 | — | — | EP | disclosed |
| WO-1995034536-A1 | PRODUCTION OF HYDROXYTHIOACETAMIDES AND USE THEREOF IN THE SYNTHESIS OF BENZOTHIOPHENES | ELI LILLY AND COMPANY (US) | 1995-12-21 | — | — | WO | disclosed |
| WO-1995034557-A1 | 2-AMINO-3-AROYL-BENZO[β]THIOPHENES AND METHOD OF MAKING THE SAME | ELI LILLY AND COMPANY (US) | 1995-12-21 | — | — | WO | disclosed |
| US-5466810-A | 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes | ELI LILLY AND COMPANY (US) | 1995-11-14 | — | — | US | disclosed |
| US-5420349-A | 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-]benzo[4-(2-aminoethoxy)-benzoyl[β]thiophenes | ELI LILLY AND COMPANY (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0062504-B1 | PROCESS FOR PREPARING 3-(4-AMINOETHOXYBENZOYL)BENZO(B)THIOPHENES | ELI LILLY AND COMPANY (US) | 1986-01-02 | — | — | EP | disclosed |
| US-4358593-A | BY ACYLATION OF PROTECTED 6-HYDROXY,2-(4-HYDROXYPHENYL) BENZO (B)THIOPHENE USING A FRIEDEL CRAFTS CATALYSTS; HYDROLYSIS | ELI LILLY AND COMPANY (US) | 1982-11-09 | — | — | US | disclosed |
| EP-0062504-A1 | Process for preparing 3-(4-aminoethoxybenzoyl)benzo(b)thiophenes | ELI LILLY AND COMPANY (US) | 1982-10-13 | — | — | EP | disclosed |