SCHEMBL7757442

SCHEMBL7757442

CC(=O)OC(CNc1ccccc1)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.52
CYP2D6 P10635 2/20 0.52
FAAH O00519 1/20 0.52
TSHR P16473 1/20 0.52
ALOX12 P18054 1/20 0.52
MAPK1 P28482 1/20 0.52
MTOR P42345 1/20 0.52
RAB9A P51151 1/20 0.52
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
BLM P54132 1/20 0.51
PMP22 Q01453 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
HTR2A P28223 6/20 0.50
ADRA1A P35348 6/20 0.50
HRH1 P35367 6/20 0.50
DRD3 P35462 6/20 0.50
SLC6A3 Q01959 6/20 0.50
OPRK1 P41145 5/20 0.50
ADORA3 P0DMS8 5/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Maleic Acid SCHEMBL8650751 0.95 CYP3A4 (0.48) CYP3A4CYP2D6FAAHTSHRALOX12
SCHEMBL7755948 0.87 SLC6A3 (0.52) CYP3A4CYP2D6FAAHTSHRALOX12
Hydrochloric Acid SCHEMBL7545277 0.86 SLC6A3 (0.51) CYP3A4CYP2D6FAAHTSHRALOX12
SCHEMBL9147119 0.83 HTR2A (0.49) CYP3A4CYP2D6FAAHTSHRALOX12
Hydrochloric Acid SCHEMBL9142630 0.82 MEN1 (0.50) CYP3A4CYP2D6FAAHTSHRALOX12
SCHEMBL4760958 0.81 CYP3A4 (0.51) CYP3A4CYP2D6FAAHTSHRALOX12
SCHEMBL8616378 0.81 CYP3A4 (0.51) CYP3A4CYP2D6FAAHTSHRALOX12
SCHEMBL8615736 0.81 CYP3A4 (0.51) CYP3A4CYP2D6FAAHTSHRALOX12
SCHEMBL8611925 0.81 SLC6A3 (0.48) CYP3A4CYP2D6FAAHTSHRALOX12
Hydrochloric Acid SCHEMBL8867248 0.81 MEN1 (0.52) CYP3A4CYP2D6FAAHTSHRALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0706796-B1 DOPAMINE RE-UPTAKE INHIBITORS FOR THE TREATMENT OF PARKINSON'S SYNDROME POLA CHEM IND INC (JP) 2001-02-28 EP claimed
US-5747493-A N-/DIPHENYLALKYL/-PIPERAZINYL-2-HYDROXYPROPYLAMINES POLA CHEMICAL INDUSTRIES, INC. (JP) 1998-05-05 US claimed
EP-0706796-A1 DOPAMINE REINCORPORATION INHIBITOR POLA CHEMICAL INDUSTRIES, INC. (JP) 1996-04-17 EP claimed
EP-0549796-B1 DIPHENYLPIPERAZINE DERIVATIVE AND DRUG FOR CIRCULATORY ORGAN CONTAINING THE SAME POLA CHEM IND INC (JP) 1998-04-29 EP disclosed
US-5391552-A Has strong antagonism against calcium with less side effects POLA CHEMICAL INDUSTRIES, INC. (JP) 1995-02-21 US disclosed
EP-0612738-A1 Diphenylpiperazine derivative and drug for circulatory organ containing the same POLA CHEMICAL INDUSTRIES, INC. (JP) 1994-08-31 EP disclosed
EP-0549796-A1 DIPHENYLPIPERAZINE DERIVATIVE AND DRUG FOR CIRCULATORY ORGAN CONTAINING THE SAME POLA CHEMICAL INDUSTRIES INC (JP) 1993-07-07 EP disclosed