Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL7757604

COc1cc(N)c(N)cc1OC.N.N

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.54
KDM4E B2RXH2 1/20 0.52
ALDH1A1 P00352 8/20 0.50
CYP3A4 P08684 5/20 0.50
TDP1 Q9NUW8 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
TSHR P16473 1/20 0.50
HSD17B10 Q99714 1/20 0.50
POLB P06746 1/20 0.50
GAA P10253 2/20 0.48
ADRA2B P18089 1/20 0.48
PTGS1 P23219 1/20 0.48
PKM P14618 1/20 0.46
MAPT P10636 2/20 0.46
MEN1 O00255 1/20 0.46
THRB P10828 1/20 0.46
KMT2A Q03164 1/20 0.46
EHMT2 Q96KQ7 1/20 0.43
ACHE P22303 1/20 0.42
CA12 O43570 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29532421 0.97 NPC1 (0.56) NPC1KDM4EALDH1A1CYP3A4TDP1
SCHEMBL209984 0.97 NPC1 (0.56) NPC1KDM4EALDH1A1CYP3A4TDP1
Hydrochloric Acid SCHEMBL5957727 0.94 NPC1 (0.54) NPC1KDM4EALDH1A1CYP3A4TDP1
Hydrochloric Acid SCHEMBL546210 0.94 NPC1 (0.54) NPC1KDM4EALDH1A1CYP3A4TDP1
Benzene SCHEMBL29154358 0.91 ALDH1A1 (0.52) NPC1KDM4EALDH1A1CYP3A4TDP1
SCHEMBL11878678 0.85 L3MBTL1 (0.61) NPC1KDM4EALDH1A1CYP3A4TDP1
SCHEMBL1708452 0.85 GAA (0.65) NPC1KDM4EALDH1A1CYP3A4TDP1
SCHEMBL926329 0.84 L3MBTL1 (0.67) NPC1KDM4EALDH1A1CYP3A4TDP1
SCHEMBL17403698 0.82 ALDH1A1 (0.46) NPC1KDM4EALDH1A1CYP3A4TDP1
SCHEMBL1225409 0.80 POLB (0.61) NPC1KDM4EALDH1A1CYP3A4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1078033-A1 METAL LIGAND CONTAINING BLEACHING COMPOSITIONS CARNEGIE-MELLON UNIVERSITY (US) 2001-02-28 EP disclosed
WO-1999058634-A1 METAL LIGAND CONTAINING BLEACHING COMPOSITIONS CARNEGIE MELLON UNIVERSITY (US) 1999-11-18 WO disclosed
EP-0923635-A2 METAL LIGAND CONTAINING BLEACHING COMPOSITIONS CARNEGIE-MELLON UNIVERSITY (US) 1999-06-23 EP disclosed
EP-0918840-A1 METAL LIGAND CONTAINING BLEACHING COMPOSITIONS CARNEGIE-MELLON UNIVERSITY (US) 1999-06-02 EP disclosed
WO-1998003626-A2 METAL LIGAND CONTAINING BLEACHING COMPOSITIONS UNIV CARNEGIE MELLON (US) 1998-01-29 WO disclosed
WO-1998003625-A1 METAL LIGAND CONTAINING BLEACHING COMPOSITIONS CARNEGIE MELLON UNIVERSITY (US) 1998-01-29 WO disclosed